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You are here: Home > Drug analysis

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  • Repatha

    Repatha

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    Repatha (evolocumab; Amgen/Astellas) is a fully human monoclonal immunoglobulin G2 antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9).

    November 20, 2019
    Find out more
  • Ibrance

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    Ibrance (palbociclib; Pfizer) is a small-molecule inhibitor of cyclin-dependent kinase 4 and 6 (CDK4/6). When associated with cyclin-D proteins, CDK4/6 are able to phosphorylate and inactivate.

    February 4, 2016
    Find out more
  • Tropifexor

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    FXR is a nuclear receptor that regulates bile acid metabolism and signaling. Activation of the receptor inhibits bile acid synthesis from cholesterol via cytochrome P450 7A1 and increases bile acid conjugation, transport, and excretion. This protects the liver from the potentially harmful effects caused during bile acid accumulation. Tropifexor (Novartis/Pfizer) is a novel, highly potent, non-bile acid FXR agonist. It has demonstrated potent activity in rodent Parkinson’s disease models by measuring the induction of FXR target genes in tissues.

    July 22, 2019
    Find out more
  • Visudyne

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    Visudyne (verteporfin; Valeant/Novartis) is a benzoporphyrin derivative photosensitizer developed for

    use in photodynamic therapy.

    April 4, 2016
    Find out more
  • Imfinzi

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    Imfinzi (durvalumab; AstraZeneca)  is a human monoclonal antibody directed against programmed death-ligand 1 (PD-L1).

    September 9, 2019
    Find out more
  • keppra report

    Keppra

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    Keppra (levetiracetam; UCB/Otsuka) boasts one of the broadest ranges of approved epilepsy

    indications of all agents in the epilepsy market, contributing to its market-leading status.

    May 23, 2017
    Find out more
  • Isatuximab

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    Isatuximab (Sanofi/ImmunoGen) is a humanized monoclonal antibody which targets cancer cells expressing the transmembrane glycoprotein CD38, which is highly expressed on malignant multiple myeloma (MM) cells, but at low levels in other tissues.

    August 9, 2018
    Find out more
  • fostemsavir

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    Fostemsavir (GSK3684934) (ViiV Healthcare), previously known as BMS-663068, is an oral prodrug of GSK2616713 (formerly BMS-626529). It is an attachment inhibitor which binds to the gp120 protein of HIV to prevent viral attachment to the host CD4+ T cells, which is necessary for entry into host cells.

    June 28, 2019
    Find out more
  • Gleevec

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    Gleevec (imatinib; Novartis) is an orally administered BCR-ABL tyrosine kinase inhibitor (TKI). The BCR-ABL fusion gene activates a number of signaling pathways that facilitate cancer cell transformation and proliferation.

    December 7, 2017
    Find out more
  • Lyxumia

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    Lyxumia (lixisenatide; Sanofi) is a member of the glucagon-like peptide-1 (GLP-1) agonist class. GLP-1 agonists are incretin mimetics, mimicking the endogenous gut hormone GLP-1, which stimulates insulin-secreting beta cells in the pancreas.

    November 7, 2017
    Find out more
  • ITCA 650

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    ITCA 650 (exenatide; Intarcia Therapeutics/Servier) is a drug-device combination currently being investigated in Phase III trials for the treatment of type 2 diabetes.

    November 7, 2017
    Find out more
  • Sorilux

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    Following its 2010 launch, Sorilux (calcipotriene; Stiefel/GlaxoSmithKline) has experienced slow

    uptake in the psoriasis market, despite having the financial support of GlaxoSmithKline. This comes as

    no surprise as the US psoriasis market is saturated with several types of established calcipotriene

    formulations, limiting Sorilux’s uptake.

    August 26, 2016
    Find out more
  • Seroquel/Seroquel XR

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    The Seroquel franchise contains quetiapine, which acts as an antagonist at multiple neurotransmitter receptors in the brain, such as serotonin 5-HT1A and 5-HT2, dopamine D1 and D2, histamine H1, and adrenergic alpha 1 and alpha 2 receptors.

    March 29, 2019
    Find out more
  • DPIV

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    DPIV is a tetravalent, AS03B-adjuvanted, purified formalin-inactivated dengue virus vaccine being developed by GlaxoSmithKline in collaboration with the US Walter Reed Army Institute of Research and the Oswaldo Cruz Foundation in Brazil.

    January 4, 2018
    Find out more
  • Ygalo

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    Ygalo (melphalan-flufenamide; Oncopeptides) is a cytotoxic alkylating agent that consists of melphalan conjugated to phenylalanine

    August 9, 2018
    Find out more
  • Semaglutide (Oral)

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    Novo Nordisk’s semaglutide is an orally available GLP-1 agonist currently being investigated in Phase
    III trials for the treatment of type 2 diabetes. GLP-1 agonists are incretin mimetics, mimicking the
    endogenous gut hormone GLP-1, which stimulates insulin-secreting beta cells in the pancreas.

    June 23, 2016
    Find out more
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This is operated by Pharma Intelligence UK Limited, a company registered in England and Wales with company number 13787459 whose registered office is 5 Howick Place, London SW1P 1WG. The Pharma Intelligence group is owned by Caerus Topco S.à r.l. and all copyright resides with the group.
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