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You are here: Home > Drug analysis

Drug analysis


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  • Alpelisib

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    Alpelisib is a p110-alpha isoform-specific PI3K inhibitor. PI3K signaling plays a fundamental role in tumorigenesis, governing cell proliferation, survival, and motility, as well as angiogenesis.

    February 5, 2016
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  • Sutent

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    Sutent (sunitinib; Pfizer) is an orally available multi-targeted tyrosine kinase inhibitor which specifically inhibits vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), c-KIT, and FLT3.

    March 6, 2019
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  • crestor report

    Crestor

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    Crestor (rosuvastatin calcium; AstraZeneca/AbbVie/Shionogi) is a member of the statin class of antidyslipidemic drugs, which competitively inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG Co-A) reductase.

    June 22, 2018
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  • Aranesp

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    Aranesp (darbepoetin alfa; Amgen/Kyowa Hakko Kirin) is a recombinant human erythropoietin product administered by intravenous or subcutaneous injection, and is indicated for the treatment of anemia in chronic kidney disease and chemotherapy-induced anemia.

    January 11, 2018
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  • Kovaltry

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    Kovaltry (Bayer) is a full-length recombinant factor VIII (rfVIII) protein that has been manufactured without using human- or animal-derived proteins throughout the manufacturing process.

    May 4, 2018
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  • Faslodex

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    Faslodex (fulvestrant; AstraZeneca) is an analog of 17 beta-estradiol, the dominant circulating estrogen, which competitively inhibits the binding of natural estradiol to the estrogen receptor (ER).

    February 2, 2016
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  • farletuzumab report

    Farletuzumab

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    Drug Overview Farletuzumab is a folate receptor alpha (FRa)-targeted monoclonal antibody being developed by Eisai. It is composed of grafted murine complementarity-determining regions on a human IgG1 kappa backbone. Inhibiting FRa can decrease cellular proliferation through inhibition of both Lyn kinase substrate phosphorylation and the interaction between Lyn tyrosine kinase and membrane signaling complexes; effectively […]

    August 17, 2017
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  • Sacituzumab govitecan

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    Sacituzumab govitecan (Immunomedics) is an antibody-drug conjugate consisting of an anti-troponin (Trop)-2 antibody conjugated to SN-38. Trop-1 and Trop-2 are type I membrane proteins expressed in human epithelial cells at various stages of differentiation. Trop1 and Trop-2 are located at contact sites between adjacent cells.

    February 26, 2020
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  • Elcon report

    Elocon

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    Elocon is a topical corticosteroid indicated for the relief of the inflammatory and pruritic

    manifestations of corticosteroid-responsive dermatoses, including atopic dermatitis, in patients aged

    two years and older.

    September 28, 2017
    Find out more
  • FluMist QIV

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    FluMist QIV (AstraZeneca/Daiichi Sankyo) is a quadrivalent live-attenuated influenza vaccine containing antigens from two A strains and two B strains specified by the World Health Organization seasonally for influenza vaccination.

    January 10, 2019
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  • omadacycline

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    Omadacycline (Paratek Pharmaceuticals) is the first agent of the aminomethycyclines class of antibiotics. The drug, which is a semisynthetic derivative of the tetracycline minocycline.

    June 19, 2015
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  • Daklinza

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    Daklinza (daclatasvir; Bristol-Myers Squibb) is a first-generation NS5A inhibitor approved for use for the treatment of genotype 1/2/3/4 (GT-1/2/3/4) chronic hepatitis C virus patients. Within the US and five major EU markets (France, Germany, Italy, Spain, and the UK), Daklinza is also approved for use in combination with Sovaldi (sofosbuvir; Gilead) for the treatment of GT-1/3 patients.

    November 6, 2017
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  • Genvoya

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    Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate [TAF]; Gilead) is a single-tablet regimen (STR) approved for the treatment of HIV-1 infection.

    June 28, 2019
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  • Zeltherva

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    Zeltherva’s (galinpepimut-S; SELLAS Life Sciences Group) larger target patient population gives it more commercial potential than other drugs being positioned towards the maintenance setting.

    July 6, 2017
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  • Zydelig

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    Zydelig (idelalisib; Gilead) is an oral, highly selective inhibitor of the phosphoinositide 3-kinase (PI3K) isoform p110-delta. In vitro studies have demonstrated that Zydelig results in decreased phosphorylation Akt and other downstream effectors, an increase in poly (ADP-ribose) polymerase and caspase cleavage, and an induction of apoptosis.

    January 31, 2019
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