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Fitusiran
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Alnylam, in conjunction with its development partner Sanofi, is developing fitusiran for the treatment of hemophilia A and B.
May 4, 2018
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Selonsertib
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Selonsertib (Gilead) is a small molecule that inhibits apoptosis signal-regulating kinase 1 (ASK1). ASK1 has been shown to promote inflammation, apoptosis, and fibrosis in settings of oxidative stress. Non-alcoholic steatohepatitis (NASH) increases oxidative stress and ASK1 activation, so by inhibiting ASK1, selonsertib has been shown to decrease inflammation and fibrosis in patients with NASH.
July 22, 2019
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Ensartinib
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Ensartinib is a second-generation ALK inhibitor developed by Xcovery. In approximately 3–5% of all NSCLC patients, abnormal ALK configuration leads to the production of proteins that promote and maintain the malignant behavior of cancer cells (Soda et al., 2008; Solomon et al., 2013).
August 30, 2018
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Lonsurf
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Lonsurf ([trifluridine + tipiracil]; Otsuka/Servier) is an oral combination drug with both anti-angiogenic and cytotoxic effects.
December 11, 2017
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Cinqair
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Cinqair (reslizumab; Teva) is a humanized monoclonal antibody which targets interleukin (IL)-5. IL-5 has been shown to play a key role in the maturation, growth, and chemotaxis of eosinophils, which are inflammatory white blood cells implicated in a number of allergic diseases, including asthma.
February 16, 2018
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Tivicay
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Tivicay (dolutegravir; ViiV Healthcare) is a once-daily, unboosted integrase inhibitor (INI) for the treatment of HIV-1 infection.
June 28, 2019
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MEDI8897
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MEDI8897 is a human immunoglobulin G1 MAb derived from human B cells intended to provide protection against RSV infection.
October 5, 2018
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Kovaltry
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Kovaltry (Bayer) is a full-length recombinant factor VIII (rfVIII) protein that has been manufactured without using human- or animal-derived proteins throughout the manufacturing process.
May 4, 2018
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Tymlos transdermal patch
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Tymlos (abaloparatide; Radius Health) is a synthetic peptide analog of human parathyroid hormone-related protein (PTHrP), which binds to the same receptor as parathyroid hormone (PTH).
October 8, 2019
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Vericiguat
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Vericiguat is a first-in-class soluble guanylate cyclase (sGC) stimulator that acts to increase levels of cyclic guanosine monophosphate (cGMP) via the nitric oxide-sGC-cGMP pathway.
December 11, 2017
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MPC-150-IM
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MPC-150-IM (rexlemestrocel-L; Mesoblast) consists of highly purified, immunoselected mesenchymal precursor cells (MPCs).
December 11, 2017
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Rebif
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Originally developed by Merck KGaA, Rebif was first launched in the EU in 1998, followed by launch in the US in March 2002.
November 24, 2017
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Daklinza
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Daklinza (daclatasvir; Bristol-Myers Squibb) is a first-generation NS5A inhibitor approved for use for the treatment of genotype 1/2/3/4 (GT-1/2/3/4) chronic hepatitis C virus patients. Within the US and five major EU markets (France, Germany, Italy, Spain, and the UK), Daklinza is also approved for use in combination with Sovaldi (sofosbuvir; Gilead) for the treatment of GT-1/3 patients.
November 6, 2017
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Provenge
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Provenge (sipuleucel-T; Sanpower Group) is a cellular immunotherapy composed of autologous dendritic cells loaded with the recombinant antigen prostatic acid phosphatase (PAP), which is expressed on approximately 95% of prostate tumor cells.
January 18, 2018
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Flublok
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Flublok (Sanofi) is a quadrivalent recombinant seasonal influenza vaccine that contains antigens from two A strains and two B strains specified by the World Health Organization seasonally for influenza vaccination.
January 10, 2019
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