EXECUTIVE SUMMARY…………………………………………………………………………. ES-1
i. Tissue-engingeered skin replacement and substitutes………………. ES-1
ii. Active wound repair modulators …………………………………………….. ES-4
iii. Advanced wound closure products…………………………………………. ES-5
iv. Advanced wound dressings…………………………………………………… ES-7
v. Market analysis …………………………………………………………………. ES-11
vi. Methodology……………………………………………………………………… ES-14

Exhibit ES-1: Advanced wound care products, market forecast, 2015-20………. ES-12

1. TISSUE-ENGINEERED SKIN REPLACEMENTS AND SUBSTITUTES….. 1-1
1.1 Allografts ………………………………………………………………………………. 1-1
1.2 Autografts ……………………………………………………………………………… 1-2
1.3 Xenografts …………………………………………………………………………….. 1-3
1.4 Autologous and tissue-engineered skin replacements/substitutes …. 1-4
1.4.1 Epidermal equivalent products …………………………………… 1-5
1.4.2 Dermal equivalent products……………………………………….. 1-8
1.4.3 Multilayer equivalent products ……………………………………. 1-9
1.4.4 Amniotic tissue grafts ……………………………………………… 1-11
1.5 Market forecast…………………………………………………………………….. 1-12
1.6 Competitive analysis……………………………………………………………… 1-15
1.7 Bibliography…………………………………………………………………………. 1-19

Exhibit 1-1: Tissue-engineered skin replacements and substitutes, market forecast, 2015-20……………………………………………………….. 1-16
Exhibit 1-2: Tissue-engineered skin replacements and substitutes market, share by supplier, 2015 …………………………………………………………. 1-18

2. ACTIVE WOUND REPAIR MODULATORS………………………………………… 2-1
2.1 Growth factors ……………………………………………………………………….. 2-1
2.1.1 Growth factor classification………………………………………… 2-3
2.1.1.1 Fibroblast growth factor………………………………. 2-4
2.1.1.2 Transforming growth factor …………………………. 2-6
2.1.1.3 Epidermal growth factor ……………………………… 2-7
2.1.1.4 Platelet-derived growth factor………………………. 2-8
2.1.1.5 Insulin-like growth factor……………………………… 2-8
2.1.1.6 Keratinocyte growth factor…………………………… 2-8
2.1.1.7 Vascular endothelial growth factor ……………….. 2-9
2.1.1.8 Autologous growth factor…………………………… 2-10
2.1.1.9 Summary of angiogenic growth factors ……….. 2-11
2.1.2 Competitors and products ……………………………………….. 2-11
2.1.3 Market forecast………………………………………………………. 2-14
2.2 Gene therapy agents…………………………………………………………….. 2-16
2.3 Stem cells……………………………………………………………………………. 2-19
2.3.1 Types of stem cells…………………………………………………. 2-19
2.3.1.1 Embryonic stem cells ……………………………….. 2-20
2.3.1.2 Adult stem cells ……………………………………….. 2-22
2.3.1.3 Cord blood stem cells……………………………….. 2-24
2.3.2 The role of stem cells in wound healing……………………… 2-25
2.3.3 Market status…………………………………………………………. 2-26
2.4 Other active wound repair modulators and pharmaceuticals……….. 2-26
2.4.1 Antibiotics and anti-infectives …………………………………… 2-27
2.4.2 Hormones……………………………………………………………… 2-27
2.4.3 Matrix metalloproteinase enzyme inhibitors………………… 2-28
2.4.4 Neuropeptides in diabetic wounds…………………………….. 2-29
2.4.5 Other products……………………………………………………….. 2-29
2.5 Bibliography…………………………………………………………………………. 2-31

Exhibit 2-1: Selected growth factors in development for wound healing applications ……………………………………………………… 2-5
Exhibit 2-2: The angiogenesis process……………………………………………………… 2-12
Exhibit 2-3: Selected angiogenic growth factors, 2016………………………………… 2-13
Exhibit 2-4: Growth factors, market forecast, 2015-20 ………………………………… 2-17

3. ADVANCED WOUND CLOSURE PRODUCTS MARKET …………………….. 3-1
3.1 Surgical sealants and glues……………………………………………………… 3-1
3.1.1 Applications…………………………………………………………….. 3-2
3.1.2 Fibrin sealants …………………………………………………………. 3-4
3.1.2.1 Composition ……………………………………………… 3-5
3.1.2.2 Application methods …………………………………… 3-6
3.1.3 Autologous-processed sealants …………………………………. 3-7
3.1.4 Collagen- and albumin-based sealants ……………………….. 3-8
3.1.5 Cyanoacrylate-based sealants …………………………………… 3-8
3.1.6 Polymer-based sealants………………………………………….. 3-10
3.1.7 Market analysis ……………………………………………………… 3-10
3.1.8 Competitive analysis ………………………………………………. 3-12
3.2 Energy-based wound closure products ……………………………………. 3-14
3.2.1 Radiofrequency closure…………………………………………… 3-14
3.2.1.1 Monopolar/bipolar…………………………………….. 3-16
3.2.2 Ultrasonic closure…………………………………………………… 3-16
3.2.3 Thermal closure……………………………………………………… 3-17
3.2.4 Market analysis ……………………………………………………… 3-17
3.2.5 Competitive analysis ………………………………………………. 3-18
3.3 Automated suturing devices …………………………………………………… 3-22
3.3.1 Market analysis ……………………………………………………… 3-23
3.3.2 Competitive analysis ………………………………………………. 3-25
3.4 Negative pressure wound therapy…………………………………………… 3-25
3.4.1 Market analysis ……………………………………………………… 3-28
3.4.2 Competitive analysis ………………………………………………. 3-30
3.5 Combined market analysis …………………………………………………….. 3-32
3.6 Bibliography…………………………………………………………………………. 3-36

Exhibit 3-1: Surgical sealants and glues, market forecast, 2015-20………………. 3-13
Exhibit 3-2: Surgical sealants and glues market, share by supplier, 2015………. 3-15
Exhibit 3-3: Energy-based wound closure devices, market forecast, 2015-20 .. 3-19
Exhibit 3-4: Energy-based wound closure devices market, share by supplier, 2015 …………………………………………………………. 3-21
Exhibit 3-5: Automated suturing products, market forecast, 2015-20…………….. 3-26
Exhibit 3-6: Automated suturing products market, share by supplier, 2015…….. 3-27
Exhibit 3-7: Negative pressure wound therapy products, market forecast, 2015-20……………………………………………………….. 3-31
Exhibit 3-8: Negative pressure wound therapy products market, share by supplier, 2015 …………………………………………………………. 3-33
Exhibit 3-9: Advanced wound closure products, combined market forecast, 2015-20………………………………………………………………….. 3-34

4. ADVANCED WOUND DRESSINGS…………………………………………………… 4-1
4.1 Alginate dressings ………………………………………………………………….. 4-2
4.1.1 Market forecast………………………………………………………… 4-3
4.1.2 Competitive analysis ………………………………………………… 4-4
4.2 Film dressings ……………………………………………………………………….. 4-6
4.2.1 Market forecast………………………………………………………… 4-8
4.2.2 Competitive analysis ………………………………………………… 4-9
4.3 Foam dressings……………………………………………………………………. 4-11
4.3.1 Market forecast………………………………………………………. 4-14
4.3.2 Competitive analysis ………………………………………………. 4-15
4.4 Hydrocolloid dressings ………………………………………………………….. 4-17
4.4.1 Market forecast………………………………………………………. 4-20
4.4.2 Competitive analysis ………………………………………………. 4-23
4.5 Hydrogel wound care products……………………………………………….. 4-24
4.5.1 Market forecast………………………………………………………. 4-27
4.5.2 Competitive analysis ………………………………………………. 4-28
4.6 Wound contact layer dressings ………………………………………………. 4-30
4.6.1 Market forecast………………………………………………………. 4-32
4.6.2 Competitive analysis ………………………………………………. 4-33
4.7 Antimicrobial dressings………………………………………………………….. 4-35
4.7.1 Market forecast………………………………………………………. 4-38
4.7.2 Competitive analysis ………………………………………………. 4-39
4.8 Combined market analysis …………………………………………………….. 4-41
4.9 Bibliography…………………………………………………………………………. 4-46
Exhibit 4-1: Alginate wound dressings, market forecast, 2015-20…………………… 4-5
Exhibit 4-2: Alginate wound dressings market, share by supplier, 2015…………… 4-7
Exhibit 4-3: Film wound dressings, market forecast, 2015-20 ………………………. 4-10
Exhibit 4-4: Film wound dressings market, share by supplier, 2015………………. 4-12
Exhibit 4-5: Foam wound dressings, market forecast, 2015-20…………………….. 4-16
Exhibit 4-6: Foam wound dressings market, share by supplier, 2015 ……………. 4-18
Exhibit 4-7: Hydrocolloid wound dressings, market forecast, 2015-20 …………… 4-22
Exhibit 4-8: Hydrocolloid wound dressings market, share by supplier, 2015…… 4-25
Exhibit 4-9: Hydrogel wound care products, market forecast, 2015-20 ………….. 4-29
Exhibit 4-10: Hydrogel wound care products market, share by supplier, 2015….. 4-31
Exhibit 4-11: Wound contact layer dressings, market forecast, 2015-20………….. 4-34
Exhibit 4-12: Wound contact layer dressings market, share by supplier, 2015 … 4-36
Exhibit 4-13: Silver-containing antimicrobial wound dressings, market forecast, 2015-20……………………………………………………….. 4-40
Exhibit 4-14: Silver-containing antimicrobial wound dressings market, share by supplier, 2015 …………………………………………………………. 4-42
Exhibit 4-15: Advanced wound dressings, combined market forecast, 2015-20 .. 4-44
APPENDIX: COMPANY LISTING……………………………………………………………… A-1