Highlights

• I am not sure it is worth paying $450 a month for a drug that improves your performance by less than 10%, and I did say I use these drugs, I am not saying they are worthless, they are just really very disappointing, and my hope is that when there is going to be new drugs, we are not going to be arguing over whether 4% or 5% or 3% or 2% is enough, especially if it is a drug that costs $40,000 a month.
• I am concerned that in the trials that are targeting earlier and earlier non-symptomatic patients, or asymptomatic patients, that the efficacy of the trials must depend on the clinical outcome, not the biomarkers, and that may take longer, right? So, if a three- or four-year clinical trial shows that the plaques are removed from the brain, and the tau levels in the spinal fluid goes down, that would not be adequate for me because in a three- or four-year trial of an asymptomatic patient, nothing may have happened to their cognition.
• I am just worried that there are going to be drugs approved which have not been shown to be effective in the clinical outcome, which is the only thing that matters.