TABLE OF CONTENTS

EXECUTIVE SUMMARY …………………………………………………………………………. ES-1
i. Cardiovascular diseases overview …………………………………………. ES-1
ii. Global angioplasty catheters market ………………………………………. ES-1
a. Market drivers and limiters ……………………………………… ES-3
b. Device segment insights…………………………………………. ES-4
c. Technology trends …………………………………………………. ES-5
d. Market leaders ………………………………………………………. ES-6
e. Competitive strategies ……………………………………………. ES-6
f. Emerging competition …………………………………………….. ES-7
iii. Methodology ……………………………………………………………………….. ES-7
Exhibit ES-1: Angioplasty catheters global market forecast, 2016-21 ……………. ES-2
Exhibit ES-2: Global angioplasty catheters market, share by country/region, 2016 ………………………………………………………….. ES-3
Exhibit ES-3: Drivers and limiters of growth on the angioplasty catheters market ……………………………………………………………….. ES-4

1. CARDIOVASCULAR DISEASES OVERVIEW …………………………………….. 1-1
1.1 Acute coronary syndrome ………………………………………………………… 1-3
1.1.1 Atherosclerosis ………………………………………………………… 1-4
1.1.2 Angina pectoris ………………………………………………………… 1-5
1.1.3 Myocardial infarction ………………………………………………… 1-6
1.1.4 Diagnosis and treatment………………………………………….. 1-10
1.2 Hypertension ……………………………………………………………………….. 1-10
1.3 Peripheral vascular disease …………………………………………………… 1-13
1.3.1 Critical limb ischemia ………………………………………………. 1-14
1.3.2 Aneurysm ……………………………………………………………… 1-14
1.3.3 Deep vein thrombosis/pulmonary embolism ……………….. 1-15
1.3.4 Diagnosis and treatment………………………………………….. 1-17
1.4 Cerebrovascular disease ……………………………………………………….. 1-18
1.4.1 Diagnosis and treatment………………………………………….. 1-21
1.5 Bibliography …………………………………………………………………………. 1-22

Exhibit 1-1: Estimated mortality due to ischemic heart disease and cerebrovascular disease, select countries ………………………………….. 1-1
Exhibit 1-2: Top 10 countries with the highest CVD death rates……………………… 1-2
Exhibit 1-3: Estimated incident cases for acute coronary syndrome, select countries ……………………………………………………………………… 1-4
Exhibit 1-4: Age-standardized incidence (000s) of angina pectoris, select regions ………………………………………………………………………… 1-6
Exhibit 1-5: Clinical classification of acute myocardial infarction ……………………. 1-7
Exhibit 1-6: Age-standardized incidence (000s) of acute myocardial infarction, select regions ………………………………………………………….. 1-9
Exhibit 1-7: Estimated incident cases of myocardial infarction, select countries .. 1-9
Exhibit 1-8: Estimated prevalent cases of hypertension, select countries ………. 1-12
Exhibit 1-9: Mortality attributable to hypertensive diseases, select countries ….. 1-12
Exhibit 1-10: Estimated incident cases of DVT, select countries …………………….. 1-16
Exhibit 1-11: Estimated incident cases of PE, select countries ………………………. 1-17
Exhibit 1-12: Estimated incident cases of stroke, select countries ………………….. 1-20
Exhibit 1-13: Estimated prevalent cases of stroke, select countries ………………… 1-20

2. ANGIOPLASTY CATHETER PRODUCTS ………………………………………….. 2-1
2.1 Balloon angioplasty ………………………………………………………………… 2-1
2.1.1 Conventional balloon catheter products ………………………. 2-4
2.1.2 Drug-coated balloon catheter products ……………………….. 2-4
2.1.3 Drug-coated balloon catheters in development …………….. 2-7
2.1.4 Cutting balloon catheter products ……………………………… 2-12
2.1.5 Scoring balloon catheter products …………………………….. 2-15
2.2 Emerging technology …………………………………………………………….. 2-17
2.3 Bibliography …………………………………………………………………………. 2-19

Exhibit 2-1: Advantages and disadvantages of balloon angioplasty…………………. 2-2
Exhibit 2-2: Clinical requirements of balloon catheters ………………………………….. 2-2
Exhibit 2-3: Advantages and disadvantages of OTW and RX balloon catheters … 2-3
Exhibit 2-4: Select images of balloon angioplasty catheters …………………………… 2-5
Exhibit 2-5: Select balloon catheters and manufacturers ……………………………….. 2-6
Exhibit 2-6: Select images of DCB catheters ……………………………………………….. 2-8
Exhibit 2-7: Select drug-coated balloon catheters and manufacturers ……………… 2-9
Exhibit 2-8: Current clinical trials investigating drug-coated balloon catheters …. 2-10
Exhibit 2-9: Select images of cutting balloon catheters ………………………………… 2-14
Exhibit 2-10: Select images of scoring balloon catheters ……………………………… 2-16

3. ANGIOPLASTY CATHETER PRODUCTS MARKET …………………………… 3-1
3.1 Global market insights …………………………………………………………….. 3-1
3.1.1 Market value ……………………………………………………………. 3-2
3.1.2 Technology trends ……………………………………………………. 3-9
3.1.3 Market drivers and limiters ………………………………………. 3-10
3.1.4 Angioplasty catheters overview ………………………………… 3-12
3.1.5 Market leaders ……………………………………………………….. 3-14
3.1.6 Competitive strategies …………………………………………….. 3-15
3.1.7 Emerging competition ……………………………………………… 3-15
3.2 Global competitors ………………………………………………………………… 3-16
3.2.1 Balloon angioplasty catheters …………………………………… 3-16
3.2.2 Drug-coated balloon angioplasty catheters ………………… 3-17
3.2.3 Cutting balloon angioplasty catheters ………………………… 3-19
3.2.4 Scoring balloon angioplasty catheters ……………………….. 3-20
3.3 Market forecast …………………………………………………………………….. 3-21
3.3.1 Market forecast: US ………………………………………………… 3-21
3.3.2 Market forecast: five major EU markets ……………………… 3-33
3.3.3 Market forecast: Japan ……………………………………………. 3-51
3.3.4 Market forecast: RoW ……………………………………………… 3-62
3.4 Bibliography …………………………………………………………………………. 3-74

Exhibit 3-1: Angioplasty catheters, global market forecast, 2016-21 ………………… 3-3
Exhibit 3-2: Angioplasty catheter sales combined market forecast ($m), by product segment, 2016-21 …………………………………………………… 3-4
Exhibit 3-3: Global angioplasty catheters market, share by country/region, 2016 …………………………………………………………… 3-6
Exhibit 3-4: Global angioplasty catheter sales combined market forecast ($m), by country/region, 2016-21 ………………………………………………………. 3-7
Exhibit 3-5: Drivers and limiters of growth on the angioplasty catheters market …………………………………………………………………… 3-12
Exhibit 3-6: Average sale price of selected angioplasty catheters in 2017 ………. 3-13
Exhibit 3-7: Global POBA catheters market, share by supplier, 2016 …………….. 3-17
Exhibit 3-8: Global DCB catheters market, share by supplier, 2016 ………………. 3-19
Exhibit 3-9: Global scoring balloon catheters market, share by supplier, 2016 … 3-20
Exhibit 3-10: US angioplasty procedure volumes forecast (000s), 2016-21 …….. 3-23
Exhibit 3-11: US angioplasty catheter sales combined market forecast ($m), by product segment, 2016-21………………………………………………… 3-25
Exhibit 3-12: US POBA catheters market forecast, 2016-21 …………………………. 3-27
Exhibit 3-13: US POBA catheters market, share by supplier, 2016 ……………….. 3-28
Exhibit 3-14: US DCB catheters market forecast, 2016-21 …………………………… 3-29
Exhibit 3-15: US DCB catheters market, share by supplier, 2016 ………………….. 3-30
Exhibit 3-16: US cutting balloon catheters market forecast, 2016-21 ……………… 3-31
Exhibit 3-17: US scoring balloon catheters market forecast, 2016-21 …………….. 3-32
Exhibit 3-18: US scoring balloon catheters market, share by supplier, 2016 …… 3-33
Exhibit 3-19: Five major EU markets PTCA procedure volumes forecast (000s), 2016-21 ………………………………………………………. 3-36
Exhibit 3-20: Five major EU markets PTA procedure volumes forecast (000s), 2016-21 ………………………………………………………. 3-38
Exhibit 3-21: Five major EU markets angioplasty catheter sales combined market forecast ($m), by product segment, 2016-21 …………………. 3-41
Exhibit 3-22: Five major EU markets POBA catheters market forecast, 2016-21 ……………………………………………………… 3-43
Exhibit 3-23: Five major EU markets POBA catheters market, share by supplier, 2016 …………………………………………………………………. 3-44
Exhibit 3-24: Five major EU markets DCB catheters market forecast, 2016-21 .. 3-45
Exhibit 3-25: Five major EU markets DCB catheters market, share by supplier, 2016 …………………………………………………………………. 3-47
Exhibit 3-26: Five major EU markets cutting balloon catheters market forecast, 2016-21 ……………………………………………………… 3-48
Exhibit 3-27: Five major EU markets scoring balloon catheters market forecast, 2016-21 ……………………………………………………… 3-50
Exhibit 3-28: Five major EU markets scoring balloon catheters market, share by supplier, 2016 ………………………………………………………… 3-51
Exhibit 3-29: Japan angioplasty catheter sales combined market forecast ($m), by product segment, 2016-21………………………………………………… 3-52
Exhibit 3-30: Japanese PCI procedure volumes forecast, 2016-21 ……………….. 3-54
Exhibit 3-31: Japan POBA catheters market forecast, 2016-21 …………………….. 3-56
Exhibit 3-32: Japan POBA catheters market, share by supplier, 2016 ……………. 3-57
Exhibit 3-33: Japan DCB catheters market forecast, 2016-21 ………………………. 3-58
Exhibit 3-34: Japan cutting balloon catheters market forecast, 2016-21 …………. 3-59
Exhibit 3-35: Japan scoring balloon catheters market forecast, 2016-21 ………… 3-61
Exhibit 3-36: Japan scoring balloon catheters market, share by supplier, 2016 …………………………………………………………………. 3-62
Exhibit 3-37: RoW angioplasty catheter sales combined market forecast ($m), by product segment, 2016-21 …………………………… 3-63
Exhibit 3-38: RoW POBA catheters market forecast, 2016-21 ………………………. 3-67
Exhibit 3-39: RoW POBA catheters market, share by supplier, 2016 …………….. 3-68
Exhibit 3-40: RoW DCB catheters market forecast, 2016-21 ………………………… 3-69
Exhibit 3-41: RoW DCB catheters market, share by supplier, 2016 ……………….. 3-70
Exhibit 3-42: RoW cutting balloon catheters market forecast, 2016-21 …………… 3-71
Exhibit 3-43: RoW Scoring balloon catheters market forecast, 2016-21 …………. 3-72
Exhibit 3-44: RoW scoring balloon catheters market, share by supplier, 2016 …………………………………………………………………. 3-73

APPENDIX: COMPANY LISTING ……………………………………………………………… A-1