Aristada (aripiprazole lauroxil; Alkermes) is a long-acting injectable formulation of the atypical antipsychotic aripiprazole. It was developed by Alkermes using its proprietary LinkeRx technology, which allows the gradual release of aripiprazole molecules and lowers the drug’s frequency of administration.
Aristada acts as partial agonist at dopamine D2 and serotonin 5-hydroxytryptamine (HT)1A receptors, and displays antagonist activity at 5-HT2A receptors. This results in lower dopamine mesolimbic levels, and enhanced dopaminergic activity in the mesocortical pathway. Low levels of mesocortical dopamine appear to cause schizophrenia’s negative symptoms, while an excess of mesolimbic dopamine is associated with positive symptoms.
In October 2015, Aristada was approved in the US for the treatment of schizophrenia. The drug is not currently being developed for the Japanese or EU markets.
LIST OF FIGURES
10 Figure 1: Aristada for schizophrenia – SWOT analysis
11 Figure 2: Datamonitor Healthcare’s drug assessment summary of Aristada for schizophrenia
12 Figure 3: Datamonitor Healthcare’s drug assessment summary of Aristada for schizophrenia
14 Figure 4: Aristada sales for schizophrenia in the US, 2017–26
LIST OF TABLES
6 Table 1: Aristada drug profile
7 Table 2: Aristada pivotal trial data in schizophrenia
8 Table 3: Aristada other late-phase trial data in schizophrenia
9 Table 4: Aristada ongoing trial in schizophrenia
15 Table 5: Aristada sales for schizophrenia in the US ($m), 2017–26
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