EXECUTIVE SUMMARY…………………………………………………………………………. ES-1

i. Clinical Overview…………………………………………………………………. ES-1
ii. Global Market for Arthroscopy and Sports Medicine Devices……… ES-1
a. Arthroscopy devices ………………………………………………. ES-2
b. Soft tissue fixation implants…………………………………….. ES-3
iii. Methodology……………………………………………………………………….. ES-6

Exhibit ES-1: Arthroscopy and sports medicine devices, market forecast, 2016-21 ……………………………………………………………………………… ES-4

1. CLINICAL OVERVIEW …………………………………………………………………….. 1-1
1.1 Arthroscopic Knee Surgery………………………………………………………. 1-6
1.1.1 Cartilage repair………………………………………………………… 1-6
1.1.1.1 Surgical treatments ……………………………………. 1-8
1.1.2 Cartilage regeneration/tissue engineering……………………. 1-8
1.1.3 Meniscus repair……………………………………………………… 1-10
1.1.3.1 Nonoperative treatment…………………………….. 1-10
1.1.3.2 Meniscectomy …………………………………………. 1-12
1.1.3.3 Arthroscopic suturing………………………………… 1-12
1.1.3.4 Meniscal replacement ………………………………. 1-12
1.1.4 Cruciate ligament reconstruction………………………………. 1-13
1.1.4.1 Autografts……………………………………………….. 1-13
1.1.4.2 Allografts ………………………………………………… 1-13
1.2 Arthroscopic Shoulder Surgery……………………………………………….. 1-15
1.2.1 Acromioclavicular joint resection ………………………………. 1-15
1.2.2 Rotator cuff repair…………………………………………………… 1-15
1.2.3 Thermal capsular shrinkage …………………………………….. 1-16
1.2.4 Recurrent shoulder dislocation…………………………………. 1-16
1.2.5 Bankart repair………………………………………………………… 1-16
1.2.6 Superior labrum anterior to posterior lesion repair ………. 1-17
1.3 Other Arthroscopic Procedures ………………………………………………. 1-17
1.3.1 Arthroscopic elbow procedures ………………………………… 1-17
1.3.2 Arthroscopic extremities procedures …………………………. 1-18
1.3.3 Arthroscopic hip procedures…………………………………….. 1-19
1.4 Selected Arthroscopy Procedure Volumes ……………………………….. 1-22
1.4.1 US ……………………………………………………………………….. 1-22
1.4.2 5EU ……………………………………………………………………… 1-31
1.4.3 Japan……………………………………………………………………. 1-31
1.4.4 China……………………………………………………………………. 1-31
1.5 Bibliography…………………………………………………………………………. 1-32

Exhibit 1-1: Incidence of sports injuries treated at emergency departments, US, 2012 ………………………………………………………………………………. 1-2
Exhibit 1-2: Incidence of sports injuries, hospital patients, EU28, 2008-10 ………. 1-3
Exhibit 1-3: Estimates of hospital-treated sports injuries, by type of sports, EU28, 2008-10………………………………………………………………………. 1-4
Exhibit 1-4: Sports injuries, key facts and figures, EU28, 2008-10………………….. 1-5
Exhibit 1-5: Causes of articular cartilage injury…………………………………………….. 1-7
Exhibit 1-6: Outerbridge classification system for chondral damage ……………….. 1-9
Exhibit 1-7: Bucket handle tear of the medial meniscus ………………………………. 1-11
Exhibit 1-8: Graft options for anterior cruciate ligament repair ……………………… 1-14
Exhibit 1-9: Conditions amenable to arthroscopic ankle surgery…………………… 1-20
Exhibit 1-10: Conditions amenable to arthroscopic wrist surgery ……………………. 1-21
Exhibit 1-11: Arthroscopic surgery, US, procedure volumes forecast, 2015-21 ………………………………………………………………………………. 1-23
Exhibit 1-12: Arthroscopic surgery, France, procedure volumes forecast, 2015-21 ………………………………………………………………………………. 1-24
Exhibit 1-13: Arthroscopic surgery, Germany, procedure volumes forecast, 2015-21 ………………………………………………………………………………. 1-25
Exhibit 1-14: Arthroscopic surgery, Italy, procedure volumes forecast, 2015-21 ………………………………………………………………………………. 1-26
Exhibit 1-15: Arthroscopic surgery, Spain, procedure volumes forecast, 2015-21 ………………………………………………………………………………. 1-27
Exhibit 1-16: Arthroscopic surgery, UK, procedure volumes forecast, 2015-21 ………………………………………………………………………………. 1-28
Exhibit 1-17: Arthroscopic surgery, Japan, procedure volumes forecast, 2015-21 ………………………………………………………………………………. 1-29
Exhibit 1-18: Arthroscopic surgery, China, procedure volumes forecast, 2015-21 ………………………………………………………………………………. 1-30

2. ARTHROSCOPY PRODUCTS MARKET……………………………………………. 2-1
2.1 Arthroscopic Visualization Products ………………………………………….. 2-1
2.1.1 Arthroscopes …………………………………………………………… 2-1
2.1.2 Cameras…………………………………………………………………. 2-2
2.1.3 Image management systems …………………………………….. 2-3
2.1.4 Light sources …………………………………………………………… 2-4
2.1.5 Market analysis ……………………………………………………….. 2-4
2.1.6 Competitive analysis ………………………………………………… 2-6
2.2 Fluid Management Products…………………………………………………….. 2-8
2.2.1 Market analysis ……………………………………………………….. 2-9
2.2.2 Competitive analysis ………………………………………………… 2-9
2.3 Instruments (Manual)…………………………………………………………….. 2-12
2.3.1 Market analysis ……………………………………………………… 2-12
2.3.2 Competitive analysis ………………………………………………. 2-13
2.4 Instruments (Powered) ………………………………………………………….. 2-13
2.4.1 Market analysis ……………………………………………………… 2-16
2.4.2 Competitive analysis ………………………………………………. 2-17
2.5 Combined Market Analysis…………………………………………………….. 2-17
2.6 Bibliography…………………………………………………………………………. 2-23

Exhibit 2-1: Arthroscopic visualization products, global market forecast by region, 2016-21………………………………………………………………….. 2-5
Exhibit 2-2: Arthroscopic visualization products market, share by supplier, 2016 …………………………………………………………………………………….. 2-7
Exhibit 2-3: Arthroscopic fluid management products, global market forecast, by region, 2016-2021…………………………………………………………….. 2-10
Exhibit 2-4: Arthroscopic fluid management products market,share by supplier, 2016 …………………………………………………………. 2-11
Exhibit 2-5: Manual arthroscopy instruments, global market forecast, by region, 2016-21………………………………………………………………… 2-14
Exhibit 2-6: Manual arthroscopy instruments, share by supplier, 2016 ………….. 2-15
Exhibit 2-7: Powered arthroscopy instruments, market forecast, by region,2016-21 ………………………………………………………………………………. 2-18
Exhibit 2-8: Powered arthroscopy instruments, share by supplier, 2016 ………… 2-19
Exhibit 2-9: Arthroscopy products, combined market forecast, 2016-21 ………… 2-21

3. SOFT TISSUE FIXATION DEVICES ………………………………………………….. 3-1
3.1 Meniscal Fixation Devices ……………………………………………………….. 3-1
3.1.1 Nonresorbable devices……………………………………………… 3-1
3.1.2 Bioresorbable devices ………………………………………………. 3-1
3.1.3 Products …………………………………………………………………. 3-1
3.1.4 Market analysis ……………………………………………………….. 3-2
3.1.5 Competitive analysis ………………………………………………… 3-3
3.2 Cruciate Ligament Fixation Devices ………………………………………….. 3-7
3.2.1 Products …………………………………………………………………. 3-7
3.2.2 Market analysis ……………………………………………………….. 3-9
3.2.3 Competitive analysis ………………………………………………. 3-10
3.3 Shoulder Fixation Devices……………………………………………………… 3-14
3.3.1 Products ……………………………………………………………….. 3-14
3.3.1.1 Nonresorbable anchors …………………………….. 3-14
3.3.1.2 Bioresorbable anchors ……………………………… 3-16
3.3.2 Market analysis ……………………………………………………… 3-17
3.3.3 Competitive analysis ………………………………………………. 3-17
3.4 Hip Fixation Devices……………………………………………………………… 3-21
3.4.1 Products ……………………………………………………………….. 3-23
3.4.2 Market forecast………………………………………………………. 3-24
3.4.3 Competitive analysis ………………………………………………. 3-25
3.5 Extremities Fixation Devices ………………………………………………….. 3-25
3.6 Soft Tissue Fixation Devices, Combined Market Forecast and Analysis ………………………………………………………………………… 3-30
3.6.1 Key events: company acquisitions, mergers,
and restructurings…………………………………………………… 3-33
3.7 Bibliography…………………………………………………………………………. 3-34

Exhibit 3-1: Meniscal fixation devices, US market forecast, 2016-21 ………………. 3-4
Exhibit 3-2: Meniscal fixation devices, global market forecast, by region, 2016-21 ………………………………………………………………………………… 3-5
Exhibit 3-3: Meniscal fixation devices global market, share by supplier, 2016 …………………………………………………………………………………….. 3-8
Exhibit 3-4: Cruciate ligament fixation devices, US market forecast, 2016-21 ………………………………………………………………………………. 3-11
Exhibit 3-5: Cruciate ligament fixation devices, global market forecast, by region, 2016-21………………………………………………………………… 3-12
Exhibit 3-6: Cruciate ligament fixation devices global market, share by supplier, 2016 …………………………………………………………. 3-15
Exhibit 3-7: Shoulder fixation devices, US market forecast, 2016-21…………….. 3-18
Exhibit 3-8: Shoulder fixation devices, global market forecast, by region, 2016-21 ………………………………………………………………………………. 3-19
Exhibit 3-9: Shoulder fixation devices global market, share by supplier, 2016 …………………………………………………………………………………… 3-22
Exhibit 3-10: Hip fixation devices, US market forecast, 2016-21…………………….. 3-26
Exhibit 3-11: Hip fixation devices, global market forecast, by region, 2016-21 ………………………………………………………………………………. 3-27
Exhibit 3-12: Hip fixation devices global market, share by supplier, 2016 ………… 3-29
Exhibit 3-13: Soft tissue fixation devices, combined market forecast, 2016-21 ………………………………………………………………………………. 3-31

APPENDIX: COMPANY LISTING……………………………………………………………… A-1