Bosulif (bosutinib; Pfizer) is a kinase inhibitor that targets the BCR-ABL kinase and also inhibits the Src-family kinases that include Src, Lyn, and Hck. The BCR-ABL kinase is upregulated in the presence of an abnormal BCR-ABL fusion protein, which is a common hallmark of chronic myeloid leukemia (CML). Overexpression of specific Src kinases is associated with Gleevec-resistant CML phenotypes. In mice, treatment with Bosulif reduced the size of CML tumors relative to controls and inhibited growth of murine myeloid tumors expressing several Gleevec-resistant forms of BCR-ABL.
Bosulif was the fourth tyrosine kinase inhibitor (TKI) to enter the CML market and is most commonly used in the third-line setting. Bosulif benefits from its activity against CML mutations that confer resistance to Gleevec (imatinib; Novartis), Sprycel (dasatinib; Bristol-Myers Squibb/Otsuka), and Tasigna (nilotinib; Novartis). The drug failed to demonstrate a statistically significant difference in cytogenetic response versus Gleevec in the Phase III BELA trial; however, Pfizer is making a second attempt in first-line CML with the Phase III BFORE trial. Nonetheless, Bosulif’s late entry into the CML market will continue to hinder its uptake.
LIST OF FIGURES
9 Figure 1: Bosulif for CML – SWOT analysis
10 Figure 2: Datamonitor Healthcare’s drug assessment summary of Bosulif for CML
11 Figure 3: Datamonitor Healthcare’s drug assessment summary of Bosulif for CML
LIST OF TABLES
5 Table 1: Bosulif drug profile
6 Table 2: Bosulif pivotal trial data in CML
8 Table 3: Bosulif late-phase trial data in CML
Pharma Intelligence UK Limited is a company registered in England and Wales with company number 13787459 whose registered office is Suite 1, 3rd Floor, 11 - 12 St. James's Square, London, England, SW1Y 4LB. The Pharma Intelligence group is owned by Caerus Topco S.à r.l. and all copyright resides with the group.