ChAd155-RSV is a chimpanzee-derived adenovector vaccine encoding the F, N, and M2-1 proteins. The vaccine is in Phase II development for the prevention of serious lower respiratory tract disease caused by RSV in pediatric patients. GlaxoSmithKline had previously investigated a related PanAd3 vector in a prime-boost schedule with a modified vaccinia virus Ankara (MVA) vector, both of which encoded the same RSV proteins; however, the company has decided to progress with ChAd155-RSV in a standard two-dose schedule.
ChAd155-RSV (GlaxoSmithKline) is a replication-deficient chimpanzee-derived adenovector vaccine which expresses the respiratory syncytial virus (RSV) fusion (F), nucleocapsid (N), and matrix (M2-1) proteins. In preclinical studies and a single first-in-human Phase I study, related adenoviral vectors have displayed promising immunogenicity as measured by the stimulation of antigen-specific T-cell and serum-antibody responses; however, their protective efficacy is yet to be established. Importantly, the adenoviral vector is not neutralized by pre-existing antibodies, potentially allowing the vaccine to be used in neonates and young infants who are at a high risk of developing severe RSV disease, as well as in the seropositive elderly population. This is a key advantage over rival live-attenuated vaccines (LAVs), which, to date, have struggled to demonstrate immunogenicity in very young infants and seropositive individuals due to the pre-existence of neutralizing antibodies.
LIST OF FIGURES
9 Figure 1: ChAd155-RSV for RSV prophylaxis – SWOT analysis
12 Figure 2: Potential sales for RSV vaccines in infants across the US and five major EU markets, by country, 2016/17–2025/26
LIST OF TABLES 6 Table 1: ChAd155-RSV drug profile
7 Table 2: ChAd155-RSV completed clinical trial in RSV vaccination
9 Table 3: ChAd155-RSV ongoing clinical trial in RSV vaccination
13 Table 4: Potential sales for RSV vaccines in infants across the US and five major EU markets, by country ($m), 2016/17–2025/26
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