IDHIFA is an oral selective reversible inhibitor of the mutant form of the IDH2 enzyme that is associated with a wide range of cancers, including approximately 8–12% of AML cases. Mutant IDH2 is linked to the over-production of the metabolite D-2-hydroxygluterate, which inhibits cellular differentiation and can lead to the transformation of cancerous cells (Agios Pharmaceuticals, 2016).
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