Market Spotlight: Acne
Market Spotlight: Acne
$1,318.00
This Market Spotlight report covers the Acne market, comprising key pipeline and marketed drugs, clinical trials, upcoming and regulatory events, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.e forecasts.
Author: Informa Pharma Intelligence
Publisher: Datamonitor Healthcare
- Description
- Contents
This Market Spotlight report covers the Acne market, comprising key marketed and pipeline drugs, recent events and analyst opinion, clinical trials, upcoming and regulatory events, probability of success, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Key Takeaways
- Datamonitor Healthcare estimates that in 2019, there were approximately 612.5 million prevalent cases of acne worldwide, and forecasts that number to increase to 658.6 million prevalent cases by 2028. • Approved drugs in the acne space focus on a wide variety of targets. These drugs are administered via the oral and topical routes.
- The majority of industry-sponsored drugs in active clinical development for acne are in Phase II, with only one drug in the NDA/BLA phase.
- Therapies in development for acne focus on a wide variety of targets. The majority of the pipeline drugs are administered via the topical route, with the remainder being oral, subcutaneous, intranasal, or intravenous formulations.
- High-impact upcoming events for drugs in the acne space comprise topline Phase II trial results for FCD105 and an estimated PDUFA date for Winlevi/Breezula.
- The overall likelihood of approval of a Phase I dermatology-general asset is 25.9%, and the average probability a drug advances from Phase III is 75%. Drugs, on average, take 8.7 years from Phase I to approval, compared to 8.6 years in the overall dermatology space.
- The distribution of clinical trials across Phase I–IV indicates that the majority of trials for acne have been in the late phases of development, with 52% of trials in Phase III–IV, and 48% in Phase I–II.
- The US has a substantial lead in the number of acne clinical trials globally. Germany leads the major European markets, while Japan has the top spot in Asia.
- Clinical trial activity in the acne space is dominated by completed trials. GlaxoSmithKline has the highest number of completed clinical trials for acne, with 35 trials.
- GlaxoSmithKline leads industry sponsors with by far the highest overall number of clinical trials for acne, followed by AbbVie.
CONTENTS
6 OVERVIEW
7 KEY TAKEAWAYS
8 DISEASE BACKGROUND
9 TREATMENT
9 Topical therapy
9 Systemic therapy
10 Physical treatments
11 EPIDEMIOLOGY
14 MARKETED DRUGS
19 PIPELINE DRUGS
26 RECENT EVENTS AND ANALYST OPINION
26 Twyneo for Acne (December 30, 2019)
27 ANT-1207 for Acne (June 25, 2019)
28 VB 1953 for Acne (May 13, 2019)
29 VB 1953 for Acne (May 13, 2019)
31 Winlevi / Breezula for Acne (March 26, 2019)
32 Aklief for Acne (February 22, 2019)
35 KEY UPCOMING EVENTS
36 KEY REGULATORY EVENTS
36 Foamix Earns First Approval For Topical Minocycline With Amzeeq
36 FDA Approves Aklief Cream for Acne Treatment
36 Cassiopea Submits Acne Drug With New Mechanism Of Action
37 PROBABILITY OF SUCCESS
38 LICENSING AND ASSET ACQUISITION DEALS
38 Paratek, Almirall Partner To Bring Acne Medicine To China
38 Menlo And Foamix Merge Into Dermatology Play
38 Deals Shaping The Medical Industry, November 2019
38 Deals Shaping The Medical Industry, November 2019
40 REVENUE OPPORTUNITY
42 CLINICAL TRIAL LANDSCAPE
43 Sponsors by status
44 Sponsors by phase
46 BIBLIOGRAPHY
46 Prescription information
48 APPENDIX
LIST OF FIGURES
13 Figure 1: Trends in prevalent cases of acne, 2019–28
19 Figure 2: Overview of pipeline drugs for acne in the US
20 Figure 3: Pipeline drugs for acne, by company
20 Figure 4: Pipeline drugs for acne, by drug type
21 Figure 5: Pipeline drugs for acne, by classification
27 Figure 6: Twyneo for Acne (December 30, 2019): Phase III – SGT-65-04, Phase III – SGT-65-05
29 Figure 7: VB 1953 for Acne (May 13, 2019): Phase II – Proof-of-Concept (ex. US)
31 Figure 8: VB 1953 for Acne (May 13, 2019): Phase I – First-In-Human
32 Figure 9: Winlevi / Breezula for Acne (March 26, 2019): Phase III – CB-03-01/27 (Long-Term Extension)
34 Figure 10: Aklief for Acne (February 22, 2019): Phase III – Perfect 1, Phase III – Perfect 2
35 Figure 11: Key upcoming events in acne
37 Figure 12: Probability of success in the acne pipeline
42 Figure 13: Clinical trials in acne
42 Figure 14: Top 10 drugs for clinical trials in acne
43 Figure 15: Top 10 companies for clinical trials in acne
43 Figure 16: Trial locations in acne
44 Figure 17: Acne trials status
45 Figure 18: Acne trials sponsors, by phase
LIST OF TABLES
12 Table 1: Prevalent cases of acne, 2019–28
15 Table 2: Marketed drugs for acne
22 Table 3: Pipeline drugs for acne in the US
26 Table 4: Twyneo for Acne (December 30, 2019)
27 Table 5: ANT-1207 for Acne (June 25, 2019)
28 Table 6: VB 1953 for Acne (May 13, 2019)
30 Table 7: VB 1953 for Acne (May 13, 2019)
31 Table 8: Winlevi / Breezula for Acne (March 26, 2019)
33 Table 9: Aklief for Acne (February 22, 2019)
40 Table 10: Historical global sales, by drug ($m), 2015-19
41 Table 11: Forecasted global sales, by drug ($m), 2020–23
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