Market Spotlight: Acute Lymphoblastic Leukemia (ALL)
Market Spotlight: Acute Lymphoblastic Leukemia (ALL)
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This Market Spotlight report covers the Acute Lymphoblastic Leukemia (ALL) market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, upcoming events, probability of success, a 10-year disease incidence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Author: Informa Pharma Intelligence
Publisher: Datamonitor Healthcare
- Description
- Contents
This Market Spotlight report covers the Acute Lymphoblastic Leukemia (ALL) market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, upcoming events, probability of success, a 10-year disease incidence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Key Takeaways
- Datamonitor Healthcare estimates that in 2018, there were 86,600 incident cases of acute lymphoblastic leukemia (ALL) worldwide, and expects that number to increase to 93,500 incident cases by 2027.
- Approved drugs in the ALL space focus on a wide variety of targets. The majority of these therapies are administered via the intravenous route, with the remaining products being available in oral and intramuscular formulations.
- The highest proportion of industry-sponsored drugs in active clinical development for ALL are in Phase I, with only one drug in the NDA/BLA phase.
- Therapies in development for ALL focus on a wide variety of targets. The majority of pipeline drugs in development are administered via the intravenous route, with the remainder being oral and intramuscular formulations.
- High-impact upcoming events for drugs in the ALL space comprise topline Phase II trial results for Sarclisa, and an expected supplemental BLA filing for Tecartus.
- The overall likelihood of approval of a Phase I hematologic asset is 8.7%, and the average probability a drug advances from Phase III is 58.9%. Drugs, on average, take 9.4 years from Phase I to approval, compared to 9.6 years in the overall oncology space.
- The distribution of clinical trials across Phase I–IV indicates that the vast majority of trials for ALL have been in the early and midphases of development, with 92% of trials in Phase I–II, and only 8% in Phase III–IV.
- The US has a substantial lead in the number of ALL clinical trials globally. France leads the major European markets, while China has the top spot in Asia.
- Novartis has the highest number of completed clinical trials for ALL, with 47 trials.
- Novartis also leads industry sponsors with the highest overall number of clinical trials for ALL
CONTENTS
6 OVERVIEW
7 KEY TAKEAWAYS
8 DISEASE BACKGROUND
8 Definition
8 Patient segmentation
9 Symptoms
9 Risk factors
9 Diagnosis
11 TREATMENT
11 Chemotherapy
11 Corticosteroids
11 TKI therapy
11 Immunotherapy
12 Radiation therapy
12 Stem cell transplant
13 EPIDEMIOLOGY
16 MARKETED DRUGS
20 PIPELINE DRUGS
28 RECENT EVENTS AND ANALYST OPINION
28 Blincyto for ALL (December 10, 2019)
29 GC022 for ALL (December 7, 2019)
30 Blincyto for ALL (September 24, 2019)
32 KEY UPCOMING EVENTS
33 PROBABILITY OF SUCCESS
34 LICENSING AND ASSET ACQUISITION DEALS
34 ADC Therapeutics In Asia JV, License Deal With Overland
35 REVENUE OPPORTUNITY
37 CLINICAL TRIAL LANDSCAPE
38 Sponsors by status
39 Sponsors by phase
41 BIBLIOGRAPHY
42 Prescription information
43 APPENDIX
LIST OF FIGURES
15 Figure 1: Trends in incident cases of ALL, 2018–27
20 Figure 2: Overview of pipeline drugs for ALL in the US
20 Figure 3: Pipeline drugs for ALL, by company
21 Figure 4: Pipeline drugs for ALL, by drug type
21 Figure 5: Pipeline drugs for ALL, by classification
31 Figure 6: Blincyto for ALL (September 24, 2019): Phase III – Pediatric (1st Relapse)
32 Figure 7: Key upcoming events in ALL
33 Figure 8: Probability of success in the hematologic pipeline
37 Figure 9: Clinical trials in ALL
37 Figure 10: Top 10 drugs for clinical trials in ALL
38 Figure 11: Top 10 companies for clinical trials in ALL
38 Figure 12: Trial locations in ALL
39 Figure 13: ALL trials status
40 Figure 14: ALL trials sponsors, by phase
LIST OF TABLES
14 Table 1: Incident cases of ALL, 2018–27
17 Table 2: Marketed drugs for ALL
22 Table 3: Pipeline drugs for ALL in the US
28 Table 4: Blincyto for ALL (December 10, 2019)
29 Table 5: GC022 for ALL (December 7, 2019)
30 Table 6: Blincyto for ALL (September 24, 2019)
35 Table 7: Historical global sales, by drug ($m), 2015–19
36 Table 8: Forecasted global sales, by drug ($m), 2021–25
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