Market Spotlight: Cervical Cancer
Market Spotlight: Cervical Cancer
$1,318.00
This Market Spotlight report covers the cervical cancer market, comprising key pipeline and marketed drugs, clinical trials, upcoming events, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Publisher: Datamonitor Healthcare
- Description
- Contents
This Market Spotlight report covers the Cervical Cancer market, comprising key marketed and pipeline drugs, recent events and analyst opinion, clinical trials, upcoming and regulatory events, probability of success, licensing and acquisition deals, and a 10-year disease incidence forecast, as well as presenting drug-specific revenue forecasts.
Key Takeaways
- Datamonitor Healthcare estimates that in 2021, there were 616,600 incident cases of cervical cancer worldwide, and expects that number to increase to 665,600 incident cases by 2029.
- Approved drugs for cervical cancer target vascular endothelial growth factor, topoisomerase I, programmed death-1 receptor (PD-1)/programmed death ligands (PD-L1 and PD-L2), the immune system, reactive oxygen species/free radicals, and tissue factor. The majority of these therapies are administered via the intravenous route.
- The majority of the industry-sponsored drugs in active clinical development for cervical cancer are in Phase II, with one drug in the NDA/BLA stage.
- Therapies in development for cervical cancer focus on a wide variety of targets. The majority of the pipeline drugs are administered via the intravenous route, with the remainder being oral, subcutaneous, intramuscular, intravesical, and intranasal formulations.
- High-impact upcoming events for drugs in the cervical cancer space comprise topline Phase I/II trial results for tiragolumab, topline Phase II trial results for bintrafusp alfa, an expected PDUFA date for biosimilar bevacizumab (Mylan/Biocon), and an estimated supplemental CHMP opinion for Libtayo.
- The overall likelihood of approval of a Phase I solid tumors asset is 5.3%, and the average probability a drug advances from Phase III is 42%. Drugs, on average, take 9.9 years from Phase I to approval, compared to 9.7 years in the overall oncology space.
- The distribution of clinical trials across Phase I–IV indicates that the vast majority of trials for cervical cancer have been in the early and mid-phases of development, with 94% of trials in Phase I–II, and only 6% in Phase III–IV.
- The US has a substantial lead in the number of cervical cancer clinical trials globally. Spain leads the major European markets, while China has the top spot in Asia.
- Roche has the highest number of completed clinical trials for cervical cancer, with 19 trials. AstraZeneca leads the industry sponsors with the highest overall number of clinical trials for cervical cancer, followed closely by Merck & Co.
CONTENTS
6 OVERVIEW
7 KEY TAKEAWAYS
8 DISEASE BACKGROUND
9 TREATMENT
9 Surgery
9 Radiotherapy
9 Chemotherapy
10 Targeted therapy
10 Immunotherapy
11 EPIDEMIOLOGY
14 MARKETED DRUGS
17 PIPELINE DRUGS
23 RECENT EVENTS AND ANALYST OPINION
23 Imfinzi for Cervical Cancer (March 24, 2022)
24 Libtayo for Cervical Cancer (January 28, 2022)
25 Balstilimab for Cervical Cancer (October 22, 2021)
26 Tivdak for Cervical Cancer (September 19, 2021)
28 Keytruda for Cervical Cancer (September 18, 2021)
30 Keytruda for Cervical Cancer (June 22, 2021)
32 Libtayo for Cervical Cancer (May 12, 2021)
33 Libtayo for Cervical Cancer (March 15, 2021)
36 KEY UPCOMING EVENTS
37 KEY REGULATORY EVENTS
37 CHMP Recommends Extension Of Indication For Keytruda
37 Libtayo’s Last-Minute Withdrawal
37 China’s NMPA Accepts Lee’s NDA For Socazolimab
37 Agenus PD-1 Down But Not Out With Cervical Cancer BLA Withdrawal
38 Keytruda Cements Cervical Cancer Leadership With First-Line Nod
38 Seagen/Genmab’s Tivdak Set To Take On Merck’s Keytruda
39 PROBABILITY OF SUCCESS
40 LICENSING AND ASSET ACQUISITION DEALS
40 GSK Exits $4.2bn Cancer Drug Deal With Merck KGaA After Multiple Failures
41 REVENUE OPPORTUNITY
43 CLINICAL TRIAL LANDSCAPE
44 Sponsors by status
45 Sponsors by phase
46 Recent events
49 BIBLIOGRAPHY
50 APPENDIX
LIST OF FIGURES
13 Figure 1: Trends in incident cases of cervical cancer, 2020–29
17 Figure 2: Overview of pipeline drugs for cervical cancer in the US
17 Figure 3: Pipeline drugs for cervical cancer, by company
18 Figure 4: Pipeline drugs for cervical cancer, by drug type
18 Figure 5: Pipeline drugs for cervical cancer, by classification
24 Figure 6: Imfinzi for Cervical Cancer (March 24, 2022): Phase III – CALLA
28 Figure 7: Tivdak for Cervical Cancer (September 19, 2021): Phase I/II – innovaTV 205
30 Figure 8: Keytruda for Cervical Cancer (September 18, 2021): Phase III – KEYNOTE-826 (w/Chemotherapy, 1L)
32 Figure 9: Keytruda for Cervical Cancer (June 22, 2021): Phase III – KEYNOTE-826 (w/Chemotherapy, 1L)
33 Figure 10: Libtayo for Cervical Cancer (May 12, 2021): Phase III – vs. Chemotherapy
35 Figure 11: Libtayo for Cervical Cancer (March 15, 2021): Phase III – vs. Chemotherapy
36 Figure 12: Key upcoming events in cervical cancer
39 Figure 13: Probability of success in the solid tumors pipeline
43 Figure 14: Clinical trials in cervical cancer
43 Figure 15: Top 10 drugs for clinical trials in cervical cancer
44 Figure 16: Top 10 companies for clinical trials in cervical cancer
44 Figure 17: Trial locations in cervical cancer
45 Figure 18: Cervical cancer trials status
46 Figure 19: Cervical cancer trials sponsors, by phase
LIST OF TABLES
12 Table 1: Incident cases of cervical cancer, 2020–29
15 Table 2: Marketed drugs for cervical cancer
19 Table 3: Pipeline drugs for cervical cancer in the US
23 Table 4: Imfinzi for Cervical Cancer (March 24, 2022)
25 Table 5: Libtayo for Cervical Cancer (January 28, 2022)
26 Table 6: Balstilimab for Cervical Cancer (October 22, 2021)
27 Table 7: Tivdak for Cervical Cancer (September 19, 2021)
29 Table 8: Keytruda for Cervical Cancer (September 18, 2021)
31 Table 9: Keytruda for Cervical Cancer (June 22, 2021)
32 Table 10: Libtayo for Cervical Cancer (May 12, 2021)
34 Table 11: Libtayo for Cervical Cancer (March 15, 2021)
41 Table 12: Historical global sales, by drug ($m), 2017–21
42 Table 13: Forecasted global sales, by drug ($m), 2022–26
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