Market Spotlight: Glioblastoma (GBM)
Market Spotlight: Glioblastoma (GBM)
$1,318.00
This Market Spotlight report covers the Glioblastoma (GBM) market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, upcoming and regulatory events, probability of success, a 10-year disease incidence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Author: Informa Pharma Intelligence
Publisher: Datamonitor Healthcare
- Description
- Contents
This Market Spotlight report covers the Glioblastoma (GBM) market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, upcoming and regulatory events, probability of success, a 10-year disease incidence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Key Takeaways
- Datamonitor Healthcare estimates that in 2021, there were 80,300 incident cases of glioblastoma worldwide, and forecasts that number to increase to 91,800 incident cases by 2028.
- It is estimated that the majority of diagnosed cases in 2019 were in males. Approved drugs in the glioblastoma space focus on DNA, vascular endothelial growth factor, DNA synthesis, protein synthesis, RNA synthesis, the immune system, and oncolytic virus therapy. These drugs are administered via the intravenous, intratumoral, and oral routes for glioblastoma.
- The majority of industry-sponsored drugs in active clinical development for glioblastoma are in Phase II, with two drugs in the NDA/BLA phase.
- Therapies in mid- and late-stage development for glioblastoma focus on a wide variety of targets. The majority of pipeline drugs for glioblastoma are administered via the oral and intravenous routes.
- High-impact upcoming events for drugs in the glioblastoma space comprise topline Phase I/II, Phase II, Phase II/III, and Phase III trial results, Phase III updated trial results, an estimated PDUFA date for a BLA, and an expected CHMP opinion, as well as estimated approval decisions in the US and EU.
- The overall likelihood of approval of a Phase I solid tumors asset is 5.4%, and the average probability a drug advances from Phase III is 41.9%. Drugs, on average, take 9.8 years from Phase I to approval, compared to 9.7 years in the overall oncology space.
- The distribution of clinical trials across Phase I–IV indicates that the vast majority of trials for glioblastoma have been in the early and mid-phases of development, with 92% of trials in Phase I–II, and only 8% in Phase III–IV.
- The US has a substantial lead in the number of glioblastoma clinical trials globally. France leads the major European markets, while China has the top spot in Asia.
- Clinical trial activity in the glioblastoma space is dominated by completed trials. Roche has the highest number of completed clinical trials for glioblastoma, with 79 trials.
- Roche leads industry sponsors with the highest overall number of clinical trials for glioblastoma, followed by Merck & Co
CONTENTS
6 OVERVIEW
7 KEY TAKEAWAYS
8 DISEASE BACKGROUND
8 Disease definition
8 Patient segmentation
8 Symptoms
8 Risk factors
9 Diagnosis
10 TREATMENT
10 Surgery
10 Radiation therapy
10 Chemotherapy
10 Tumor-treating fields (TTFs)
11 Targeted therapy
12 EPIDEMIOLOGY
16 MARKETED DRUGS
19 PIPELINE DRUGS
36 RECENT EVENTS AND ANALYST OPINION
36 DNX-2401 for Glioblastoma (November 20, 2020)
37 Omburtamab for Glioblastoma (October 16, 2020)
40 KEY UPCOMING EVENTS
41 KEY REGULATORY EVENTS
41 Three-Month Dry Spell For EU PRIME Scheme
41 Pioneering Japan Approval For Daiichi’s Oncolytic Virus In Glioma
42 PROBABILITY OF SUCCESS
43 LICENSING AND ASSET ACQUISITION DEALS
43 Calidi Signs Licenses With Three Academic Partners In Oncolytic Virus Therapy
43 Kazia Therapeutics Enters Collaboration With Cornell University
43 Yale Unveils Research Pact With D&D Pharmatech
43 Lineage, Immunomic Partner On Brain Cancer Immunotherapy
44 UroGen, Johns Hopkins Investigate Brain Cancer Immunotherapy
44 Simcere Picks Up Kazia’s Paxalisib In China-Plus Area
45 REVENUE OPPORTUNITY
46 CLINICAL TRIAL LANDSCAPE
47 Sponsors by status
48 Sponsors by phase
49 Recent events
51 BIBLIOGRAPHY
53 APPENDIX
LIST OF FIGURES
14 Figure 1: Trends in incident cases of glioblastoma, 2019–28
19 Figure 2: Overview of pipeline drugs for glioblastoma in the US
19 Figure 3: Pipeline drugs for glioblastoma, by company
20 Figure 4: Pipeline drugs for glioblastoma, by drug type
20 Figure 5: Pipeline drugs for glioblastoma, by classification
37 Figure 6: DNX-2401 for Glioblastoma (November 20, 2020): Phase II – CAPTIVE/KEYNOTE-192 – w/Keytruda
39 Figure 7: Omburtamab for Glioblastoma (October 16, 2020): Phase II/III – 101 (Neuroblastoma Central Nervous System/Leptomeningeal Metastases)
40 Figure 8: Key upcoming events in glioblastoma
42 Figure 9: Probability of success in the solid tumors pipeline
46 Figure 10: Clinical trials in glioblastoma
46 Figure 11: Top 10 drugs for clinical trials in glioblastoma
47 Figure 12: Top 10 companies for clinical trials in glioblastoma
47 Figure 13: Trial locations in glioblastoma
48 Figure 14: Glioblastoma trials status
49 Figure 15: Glioblastoma trials sponsors, by phase
LIST OF TABLES
13 Table 1: Global incident cases of glioblastoma, 2019–28
15 Table 2: Incident cases of glioblastoma, by gender, 2019
17 Table 3: Marketed drugs for glioblastoma
21 Table 4: Pipeline drugs for glioblastoma in the US
36 Table 5: DNX-2401 for Glioblastoma (November 20, 2020)
38 Table 6: Omburtamab for Glioblastoma (October 16, 2020)
45 Table 7: Historical global sales, by drug ($m), 2017–21
45 Table 8: Forecasted global sales, by drug ($m), 2022–26
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