Market Spotlight: Hodgkin’s Lymphoma
Market Spotlight: Hodgkin’s Lymphoma
This Market Spotlight report covers the Hodgkin’s Lymphoma market, comprising key pipeline and marketed drugs, clinical trials, upcoming and regulatory events, patent information, a 10-year disease incidence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Author: Informa Pharma Intelligence
Publisher: Datamonitor Healthcare
This Market Spotlight report covers the Hodgkin’s Lymphoma market, comprising key marketed and pipeline drugs, clinical trials, key upcoming and regulatory events, recent events and analyst opinion, patent information, a 10-year disease incidence forecast, probability of success, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
- Datamonitor Healthcare estimates that in 2017, there were 78,600 incident cases of Hodgkin’s lymphoma worldwide, and expects that number to increase to 86,000 incident cases by 2026.
- In the same year, there were approximately 272,100 five-year prevalent cases of Hodgkin’s lymphoma worldwide, which is expected to increase to 297,700 cases by 2026.
- The approved drugs in the Hodgkin’s lymphoma space target antibody-drug conjugate, cluster of differentiation 30/tumor necrosis factor receptor superfamily member 8, microtubules, DNA, the immune system, and programmed death-1 receptor/programmed death ligands. The majority of the approved drugs are administered via the intravenous route.
- The majority of the industry-sponsored drugs in active clinical development for Hodgkin’s lymphoma are in Phase II, with no drugs in Phase III.
- Therapies in the pipeline for Hodgkin’s lymphoma focus on a wide variety of targets. The majority of the pipeline drugs in development are administered via the oral or intravenous routes, with only one product being tested in an intratumoral formulation.
- High-impact upcoming events for drugs in the Hodgkin’s lymphoma space comprise topline Phase IIa trial results for AFM13, and topline Phase III trial results for Keytruda.
- The overall likelihood of approval of a Phase I hematologic asset is 10.1%, and the average probability a drug advances from Phase III is 57.7%. Drugs, on average, take 8.8 years from Phase I to approval, compared to 9.3 years in the overall oncology space.
- There have been 41 licensing and asset acquisition deals involving Hodgkin’s lymphoma drugs during 2014–19. The largest deal was the $2,855m strategic collaboration agreement in 2014 between Pfizer and Cellectis for the development of chimeric antigen receptor T-cell (CAR-T) immunotherapies in the field of oncology directed at select targets.
- The distribution of clinical trials across Phase I–IV indicates that the vast majority of trials for Hodgkin’s lymphoma have been in the early and mid-phases of development, with 94% of trials in Phase I–II, and only 6% in Phase III–IV.
- The US has a substantial lead in the number of Hodgkin’s lymphoma clinical trials globally. France leads the major EU markets, while China has the top spot in Asia.
- Clinical trial activity in the Hodgkin’s lymphoma space is dominated by completed trials. Takeda has the highest number of completed clinical trials for Hodgkin’s lymphoma, with 47 trials.
- Takeda leads industry sponsors with by far the highest number of clinical trials for Hodgkin’s lymphoma, followed by Merck & Co.
6 KEY TAKEAWAYS
7 DISEASE BACKGROUND
9 Radiation therapy
10 Stem cell transplantation (SCT)
16 MARKETED DRUGS
19 PIPELINE DRUGS
25 RECENT EVENTS AND ANALYST OPINION
25 Folotyn for Hodgkin’s Lymphoma (January 17, 2019)
27 KEY UPCOMING EVENTS
28 KEY REGULATORY EVENTS
28 China’s Innovent Biologics Emerges As Immuno-Oncology Competitor With Sintilimab Approval
29 PROBABILITY OF SUCCESS
30 LICENSING AND ASSET ACQUISITION DEALS
31 PARENT PATENTS
32 REVENUE OPPORTUNITY
33 CLINICAL TRIAL LANDSCAPE
34 Sponsors by status
35 Sponsors by phase
37 Prescription information
LIST OF FIGURES
13 Figure 1: Trends in incident cases of Hodgkin’s lymphoma, 2017–26
19 Figure 2: Overview of pipeline drugs for Hodgkin’s lymphoma in the US
20 Figure 3: Pipeline drugs for Hodgkin’s lymphoma, by company
20 Figure 4: Pipeline drugs for Hodgkin’s lymphoma, by drug type
20 Figure 5: Pipeline drugs for Hodgkin’s lymphoma, by classification
27 Figure 6: Key upcoming events in Hodgkin’s lymphoma
29 Figure 7: Probability of success in the Hodgkin’s lymphoma pipeline
30 Figure 8: Licensing and asset acquisition deals in Hodgkin’s lymphoma, 2014–19
31 Figure 9: Parent patents in Hodgkin’s lymphoma
33 Figure 10: Clinical trials in Hodgkin’s lymphoma
33 Figure 11: Top 10 drugs for clinical trials in Hodgkin’s lymphoma
34 Figure 12: Top 10 companies for clinical trials in Hodgkin’s lymphoma
34 Figure 13: Trial locations in Hodgkin’s lymphoma
35 Figure 14: Hodgkin’s lymphoma trials status
36 Figure 15: Hodgkin’s lymphoma trials sponsors, by phase
LIST OF TABLES
12 Table 1: Incident cases of Hodgkin’s lymphoma, 2017–26
14 Table 2: Five-year prevalent cases of Hodgkin’s lymphoma, 2017–26
17 Table 3: Marketed drugs for Hodgkin’s lymphoma
22 Table 4: Pipeline drugs for Hodgkin’s lymphoma in the US
25 Table 5: Folotyn for Hodgkin’s Lymphoma (January 17, 2019)
32 Table 6: Historical global sales, by drug ($m), 2014–18
32 Table 7: Forecasted global sales, by drug ($m), 2019–23
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