Market Spotlight: Neuropathic Pain
Market Spotlight: Neuropathic Pain
This Market Spotlight report covers the neuropathic pain market, comprising key pipeline and marketed drugs, clinical trials, upcoming and regulatory events, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Author: Informa Pharma Intelligence
Publisher: Datamonitor Healthcare
This Market Spotlight report covers the neuropathic pain market, comprising key marketed and pipeline drugs, recent events and analyst opinion, clinical trials, upcoming events, probability of success, patent information, a 10-year disease prevalence forecast, and licensing and asset acquisition deals, as well as presenting drug-specific revenue forecasts.
- Datamonitor Healthcare estimates that in 2017, there were 425.2 million prevalent cases of neuropathic pain in adults aged 20 years and older worldwide, and forecasts that number to increase to 476.2 million prevalent cases by 2026.
- Asia is estimated to have had the largest number of prevalent cases in 2017, driven by population size, while having the lowest prevalence proportion (98.1 million cases; 3.2%).
- The marketed drugs in the neuropathic pain space target sodium channels, voltage-gated calcium channels, and transient receptor potential vanilloid receptor 1. These drugs are administered via the oral route, except for Qutenza, which is available as a topical formulation.
- The majority of industry-sponsored drugs in active clinical development for neuropathic pain are in Phase I. Therapies in development for neuropathic pain focus on a wide variety of targets. The majority of pipeline drugs in early- and mid-stage development are administered orally, with the remainder being intramuscular, intrathecal, intradermal, subcutaneous, and topical formulations.
- High-impact upcoming events for drugs in the neuropathic pain space comprise topline Phase IIa trial results for AP-325 and topline Phase II trial results for Dysport.
- The overall likelihood of approval of a Phase I neuropathic pain asset is 0.7%, and the average probability a drug advances from Phase III is 33.3%. Drugs, on average, take 8.9 years from Phase I to approval, compared to 9.8 years in the overall neurology space.
- There have been 28 licensing and asset acquisition deals involving neuropathic pain drugs during 2015–20, eight of which occurred in 2015. The exclusive licensing agreement in 2015 between Depomed and Janssen for the acquisition of the US rights to Nucynta, for $1.05bn, was the largest deal during the period.
- The distribution of clinical trials across Phase I–IV indicates that the majority of trials have been in the early and mid-phases of development, with 69% of trials in Phase I–II, and only 31% in Phase III–IV.
- The US has a substantial lead in the number of neuropathic pain clinical trials globally. The UK leads the major EU markets, while Japan has the top spot in Asia.
- Clinical trial activity in the neuropathic pain space is dominated by completed trials. Pfizer has the highest number of completed clinical trials for neuropathic pain, with 232 trials.
- Pfizer leads industry sponsors with by far the highest overall number of clinical trials for neuropathic pain, followed by Allergan.
7 KEY TAKEAWAYS
8 DISEASE BACKGROUND
10 Topical or focal therapies
12 Limitations of neuropathic pain prevalence estimates
17 MARKETED DRUGS
19 PIPELINE DRUGS
24 RECENT EVENTS AND ANALYST OPINION
24 VX-150 for Neuropathic Pain (December 18, 2018)
26 KEY UPCOMING EVENTS
27 KEY REGULATORY EVENTS
27 Sun Targets US Long-Term Care And Eye Care
27 Abbott Wins FDA Approval For ‘Low Dose’ Non-Rechargeable Spinal Cord Stimulator
27 Lyrica Generics Likely Delayed By A Pfizer Labeling Supplement
28 PROBABILITY OF SUCCESS
29 LICENSING AND ASSET ACQUISITION DEALS
29 Eli Lilly licenses exclusive rights to develop and sell CNTX0290 from Centrexion
30 PARENT PATENTS
31 REVENUE OPPORTUNITY
32 CLINICAL TRIAL LANDSCAPE
33 Sponsors by status
34 Sponsors by phase
35 Recent events
36 Prescription information
LIST OF FIGURES
15 Figure 1: Trends in prevalent cases of neuropathic pain, 2017–26
19 Figure 2: Overview of pipeline drugs for neuropathic pain in the US
19 Figure 3: Pipeline drugs for neuropathic pain, by company
20 Figure 4: Pipeline drugs for neuropathic pain, by drug type
20 Figure 5: Pipeline drugs for neuropathic pain, by drug classification
25 Figure 6: VX-150 for Neuropathic Pain (December 18, 2018): Phase II – Small Fiber Neuropathy
26 Figure 7: Key upcoming events in neuropathic pain
28 Figure 8: Probability of success in the neuropathic pain pipeline
29 Figure 9: Licensing and asset acquisition deals in neuropathic pain, 2015–20
30 Figure 10: Parent patents in neuropathic pain
32 Figure 11: Clinical trials in neuropathic pain
32 Figure 12: Top 10 drugs for clinical trials in neuropathic pain
33 Figure 13: Top 10 companies for clinical trials in neuropathic pain
33 Figure 14: Trial locations in neuropathic pain
34 Figure 15: Neuropathic pain trials status
35 Figure 16: Neuropathic pain trials sponsors, by phase
LIST OF TABLES
12 Table 1: Prevalence methodology
14 Table 2: Prevalent cases of neuropathic pain, 2017–26
16 Table 3: Prevalence proportions of neuropathic pain, 2017–26
18 Table 4: Marketed drugs for neuropathic pain
21 Table 5: Pipeline drugs for neuropathic pain in the US
24 Table 6: VX-150 for Neuropathic Pain (December 18, 2018)
31 Table 7: Historical global sales, by drug ($m), 2014–18
31 Table 8: Forecasted global sales, by drug ($m), 2020–24
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