This Market Spotlight report covers the Norovirus market, comprising key pipeline drugs, clinical trials, probability of success, key upcoming events, and an epidemiological overview.

Key Takeaways

• Worldwide, about one out of every five cases of acute gastroenteritis is caused by norovirus. Norovirus is responsible for approximately 685 million cases of gastroenteritis every year.
• Globally, norovirus is estimated to cause approximately 200,000 deaths annually, including an estimated 70,000 child deaths, mainly in developing countries.
• The largest proportion of industry-sponsored drugs in active clinical development for norovirus are in Phase I. All clinical candidates currently in the pipeline for norovirus are vaccines. These drugs are administered via the oral, intranasal, and intramuscular routes.
• The overall likelihood of approval of a Phase I antiviral asset is 14.3%, and the average probability a drug advances from Phase III is 74.4%. Drugs, on average, take 8.7 years from Phase I to approval, compared to 9.0 years in the overall infectious disease space.
• The distribution of clinical trials across Phase I–IV indicates that the vast majority of trials for norovirus have been in the early and mid-phases of development, with 90% of trials in Phase I–II, and only 10% in Phase III–IV.
• The US has a substantial lead in the number of norovirus clinical trials globally. Clinical trial activity in the norovirus space is dominated by completed trials. Takeda has the highest number of completed clinical trials for norovirus, with 12 trials.
• Takeda leads the industry sponsors with the highest overall number of clinical trials for norovirus.