Market Spotlight: Obesity
Market Spotlight: Obesity
$1,318.00
This Market Spotlight report covers the Obesity market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, key upcoming and regulatory events, probability of success, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Author: Informa Pharma Intelligence
Publisher: Datamonitor Healthcare
- Description
- Contents
This Market Spotlight report covers the Obesity market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, key upcoming and regulatory events, probability of success, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Key Takeaways
- Datamonitor Healthcare estimates that in 2017, there were approximately 681.3 million prevalent cases of obesity in adults (aged 20+ years) worldwide, and expects that number to increase to 762.9 million prevalent cases by 2026.
- In the same year, Datamonitor Healthcare estimates that there were 126.6 million prevalent cases of obesity in children and adolescents (aged 5–19 years) worldwide, and expects that number to increase to 134.0 million prevalent cases by 2026.
- Prevalence proportions are highest in Northern America and lowest in Asia. The approved drugs in the obesity space target gastric lipase, dopamine, norepinephrine (noradrenaline), dopamine reuptake, norepinephrine (noradrenaline) reuptake/transporter, opioid receptors, GABA-A receptor, and glucagon-like peptide-1 (GLP-1) receptor. The majority of marketed drugs are administered via the oral route, with one product being available in a subcutaneous formulation.
- The majority of industry-sponsored drugs in active clinical development for obesity are in Phase I, with two drugs in Phase III. Therapies in development for obesity focus on a wide variety of targets, with the subcutaneous route being the most common method of delivery.
- High-impact upcoming events for drugs in the obesity space comprise an expected PDUFA date, a decentralized EU approval, and an estimated EU patent expiration for Qsymia.
- The overall likelihood of approval of a Phase I obesity asset is 2.6%, and the average probability a drug advances from Phase III is 62.5%. Drugs, on average, take 8.6 years from Phase I to approval, compared to 8.9 years in the overall metabolic space.
- The distribution of clinical trials across Phase I–IV indicates that the majority of trials for obesity have been in the early and midphases of development, with 66% of trials in Phase I–II, and 34% in Phase III–IV.
- The US has a substantial lead in the number of obesity clinical trials globally. The UK leads the major European markets, while Japan has the top spot in Asia.
- Clinical trial activity in the obesity space is dominated by completed trials. AstraZeneca has the highest number of completed clinical trials for obesity, with 78 trials.
- Novo Nordisk leads industry sponsors with the highest overall number of clinical trials for obesity, followed by AstraZeneca.
CONTENTS
6 OVERVIEW
7 KEY TAKEAWAYS
8 DISEASE BACKGROUND
9 TREATMENT
9 Medications
9 Surgery
11 EPIDEMIOLOGY
17 MARKETED DRUGS
19 PIPELINE DRUGS
25 RECENT EVENTS AND ANALYST OPINION
25 AM833 for Obesity (June 18, 2020)
27 Ozempic for Obesity (June 12, 2020)
28 Ozempic for Obesity (June 4, 2020)
30 Ozempic for Obesity (May 13, 2020)
32 Tesomet for Obesity (April 22, 2020)
34 Efpeglenatide for Obesity (December 10, 2019)
35 Efinopegdutide for Obesity (July 3, 2019)
36 NS-0200 for Obesity (June 8, 2019)
38 PLENITY for Obesity (April 14, 2019)
39 PLENITY for Obesity (March 25, 2019)
43 KEY UPCOMING EVENTS
44 KEY REGULATORY EVENTS
44 MAAs Under Review/Rhythm Files Setmelanotide
44 EMA Considers Fast-Tracking Rhythm’s Insatiable Hunger and Obesity Disorders Drug
44 Three Fast Track Drugs Stand Out In Flurry Of Submissions
44 FDA Requests Belviq Be Pulled From The US Market Due To Cancer Risk
45 Preparing For Qsymia Launch In Korea
46 PROBABILITY OF SUCCESS
47 LICENSING AND ASSET ACQUISITION DEALS
47 CMS Pays $35m For China Rights To Gelesis Obesity Therapy
47 Novo/Fauna Partnership Includes Options To Resulting Drug Candidates
47 Novo Nordisk Enters Its First Strategic RNAi Pact
48 CLINICAL TRIAL LANDSCAPE
49 Sponsors by status
50 Sponsors by phase
51 Recent events
53 BIBLIOGRAPHY
53 Prescription information
54 APPENDIX
LIST OF FIGURES
13 Figure 1: Trends in prevalent cases of obesity in adults, 2017–26
19 Figure 2: Overview of pipeline drugs for obesity in the US
19 Figure 3: Pipeline drugs for obesity, by company
20 Figure 4: Pipeline drugs for obesity, by drug type
20 Figure 5: Pipeline drugs for obesity, by classification
26 Figure 6: AM833 for Obesity (June 18, 2020): Phase I – w/Semaglutide / Phase II – 4433
27 Figure 7: AM833 for Obesity (June 18, 2020): Phase I – w/Semaglutide / Phase II – 4433
28 Figure 8: Ozempic for Obesity (June 12, 2020): Phase IIIa – STEP 2 (Overweight/obese diabetics), Phase IIIa – STEP 3 (Maximizing Weight Loss)
30 Figure 9: Ozempic for Obesity (June 4, 2020): Phase IIIa – STEP 1 (Weight Loss)
32 Figure 10: Ozempic for Obesity (May 13, 2020): Phase IIIa – STEP 4 (Maintained Weight Loss)
34 Figure 11: Tesomet for Obesity (April 22, 2020): Phase IIa – Hypothalamic Obesity (Denmark)
38 Figure 12: NS-0200 for Obesity (June 8, 2019): Phase II – NS-WM-01
43 Figure 13: Key upcoming events in obesity
46 Figure 14: Probability of success in the obesity pipeline
48 Figure 15: Clinical trials in obesity
48 Figure 16: Top 10 drugs for clinical trials in obesity
49 Figure 17: Top 10 companies for clinical trials in obesity
49 Figure 18: Trial locations in obesity
50 Figure 19: Obesity trials status
51 Figure 20: Obesity trials sponsors, by phase
LIST OF TABLES
12 Table 1: Prevalent cases of obesity in adults, 2017–26
14 Table 2: Prevalent cases of morbid obesity in adults, 2017–26
15 Table 3: Prevalent cases of obesity in children and adolescents, 2017–26
16 Table 4: Prevalence proportions of obesity and morbid obesity, 2017
18 Table 5: Marketed drugs for obesity
21 Table 6: Pipeline drugs for obesity in the US
25 Table 7: AM833 for Obesity (June 18, 2020)
27 Table 8: Ozempic for Obesity (June 12, 2020)
29 Table 9: Ozempic for Obesity (June 4, 2020)
31 Table 10: Ozempic for Obesity (May 13, 2020)
32 Table 11: Tesomet for Obesity (April 22, 2020)
35 Table 12: Efpeglenatide for Obesity (December 10, 2019)
36 Table 13: Efinopegdutide for Obesity (July 3, 2019)
37 Table 14: NS-0200 for Obesity (June 8, 2019)
38 Table 15: PLENITY for Obesity (April 14, 2019)
40 Table 16: PLENITY for Obesity (March 25, 2019
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