Market Spotlight: Obesity
Market Spotlight: Obesity
$1,318.00
This Market Spotlight report covers the Obesity market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, upcoming and regulatory events, probability of success, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecast
Publisher: Datamonitor Healthcare
- Description
- Contents
This Market Spotlight report covers the Obesity market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, upcoming and regulatory events, probability of success, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Key Takeaways
- Datamonitor Healthcare estimates that in 2021, there were approximately 694.0 million prevalent cases of obesity in adults (aged 20+ years) worldwide, and expects that number to increase to 758.5 million prevalent cases by 2029.
- In the same year, Datamonitor Healthcare estimates that there were 126.3 million prevalent cases of obesity in children and adolescents (aged 5–19 years) worldwide, and expects that number to increase to 128.3 million prevalent cases by 2029.
- Prevalence proportions are highest in Northern America and lowest in Asia. The approved drugs in the obesity space target gastric lipase, dopamine, norepinephrine (noradrenaline), dopamine reuptake, norepinephrine (noradrenaline) reuptake/transporter, opioid receptors, GABA-A receptor, and glucagon-like peptide-1 (GLP-1) receptor. The majority of marketed drugs are administered via the oral route, with two products being available in a subcutaneous formulation.
- The largest proportion of industry-sponsored drugs in active clinical development for obesity are in Phase I, with two drugs in Phase III.
- Therapies in development for obesity focus on a wide variety of targets. These therapies are commonly administered via the subcutaneous or oral routes, with one drug being tested in an intravenous formulation.
- High-impact upcoming events for drugs in the obesity space comprise topline Phase I trial results for ZP8396; topline Phase II trial results for PF-06882961, pemvidutide, BI 456906, and ARD-101; topline Phase IIb trial results for Tesomet; topline Phase III trial results for Mounjaro; and an estimated EU patent expiration for Qsymia.
- The overall likelihood of approval of a Phase I obesity asset is 2.2%, and the average probability a drug advances from Phase III is 66.7%. Drugs, on average, take 8.3 years from Phase I to approval, compared to 9.7 years in the overall metabolic space.
- The distribution of clinical trials across Phase I–IV indicates that the majority of trials for obesity have been in the early and midphases of development, with 64% of trials in Phase I–II, and 36% in Phase III–IV.
- The US has a substantial lead in the number of obesity clinical trials globally. The UK leads the major European markets, while Japan has the top spot in Asia.
- Clinical trial activity in the obesity space is dominated by completed trials. Novo Nordisk has the highest number of completed clinical trials for obesity, with 87 trials.
- Novo Nordisk leads industry sponsors with the highest overall number of clinical trials for obesity, followed by AstraZeneca.
CONTENTS
6 OVERVIEW
7 KEY TAKEAWAYS
8 DISEASE BACKGROUND
9 TREATMENT
9 Medications
9 Surgery
11 EPIDEMIOLOGY
19 MARKETED DRUGS
21 PIPELINE DRUGS
28 RECENT EVENTS AND ANALYST OPINION
28 Multiple Drugs for Obesity (June 6, 2022)
30 Mounjaro for Obesity (June 4, 2022)
33 Mounjaro for Obesity (April 28, 2022)
35 Ozempic for Obesity (June 26, 2021)
38 Tirzepatide for Obesity (June 25, 2021)
43 KEY UPCOMING EVENTS
44 KEY REGULATORY EVENTS
44 Rhythm Wins Reimbursement For Obesity Drug Imcivree In France & England
44 Rhythm Leans On Imcivree Rare Disease Commercialization For New Indication
44 Scotland Okays Funding For Novo Nordisk’s Saxenda
45 Imcivre Needs More Subgroup Analyses Of Clinical Efficacy
45 England Funding Win for Wegovy
45 Novo Nordisk’s Wegovy Gets EU Thumbs Up But Launch Will Wait
47 PROBABILITY OF SUCCESS
48 LICENSING AND ASSET ACQUISITION DEALS
48 Novo Nordisk Links Up With EraCal To Develop New Obesity-Related Drug Targets
48 Lilly Teams With Regor On Metabolic Disorders
48 RareStone Licenses Obesity Drug From Rhythm Pharmaceuticals
48 Sciwind Licenses Global Rights To Develop Sanofi’s Long-Lasting GIP Receptor Agonists
49 RNAi Returns To Spotlight As Novo Nordisk Swoops For Dicerna
49 D&D Pharmatech Signs Licensing And Development Agreement For DD01 With Shenzhen Pregene In China
49 CinFina Gets Four Early-Stage Obesity Injectables From Janssen
51 REVENUE OPPORTUNITY
52 CLINICAL TRIAL LANDSCAPE
53 Sponsors by status
54 Sponsors by phase
55 Recent events
58 BIBLIOGRAPHY
59 APPENDIX
LIST OF FIGURES
13 Figure 1: Trends in prevalent cases of obesity in adults, 2020–29
16 Figure 2: Trends in prevalent cases of obesity in children and adolescents, 2020–29
21 Figure 3: Overview of pipeline drugs for obesity in the US
21 Figure 4: Pipeline drugs for obesity, by company
22 Figure 5: Pipeline drugs for obesity, by drug type
22 Figure 6: Pipeline drugs for obesity, by classification
30 Figure 7: Pemvidutide for Obesity (June 6, 2022): Phase I – ALT-801-101 (Australia)
30 Figure 8: ZP7570 for Obesity (June 6, 2022): Phase Ib – MAD
33 Figure 9: Mounjaro for Obesity (June 4, 2022): Phase III – SURMOUNT-1
35 Figure 10: Mounjaro for Obesity (April 28, 2022): Phase III – SURMOUNT-1
38 Figure 11: Ozempic for Obesity (June 26, 2021): Phase IIIa – STEP 2 (Overweight/obese diabetics)
42 Figure 12: Tirzepatide for Obesity (June 25, 2021): Phase III – SURPASS-2 (vs. Semaglutide)
43 Figure 13: Key upcoming events in obesity
47 Figure 14: Probability of success in the obesity pipeline
52 Figure 15: Clinical trials in obesity
52 Figure 16: Top 10 drugs for clinical trials in obesity
53 Figure 17: Top 10 companies for clinical trials in obesity
53 Figure 18: Trial locations in obesity
54 Figure 19: Obesity trials status
55 Figure 20: Obesity trials sponsors, by phase
LIST OF TABLES
12 Table 1: Prevalent cases of obesity in adults, 2020–29
14 Table 2: Prevalent cases of morbid obesity in adults, 2020–29
15 Table 3: Prevalent cases of obesity in children and adolescents, 2020–29
17 Table 4: Prevalence proportions of obesity and morbid obesity, 2020
20 Table 5: Marketed drugs for obesity
23 Table 6: Pipeline drugs for obesity in the US
28 Table 7: Multiple Drugs for Obesity (June 6, 2022)
31 Table 8: Mounjaro for Obesity (June 4, 2022)
34 Table 9: Mounjaro for Obesity (April 28, 2022)
36 Table 10: Ozempic for Obesity (June 26, 2021)
38 Table 11: Tirzepatide for Obesity (June 25, 2021)
51 Table 12: Historical global sales, by drug ($m), 2017–21
51 Table 13: Forecasted global sales, by drug ($m), 2022–26
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