Market Spotlight: Pancreatic Cancer
Market Spotlight: Pancreatic Cancer
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This Market Spotlight report covers the Pancreatic Cancer market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, upcoming events, probability of success, a 10-year disease incidence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Author: Informa Pharma Intelligence
Publisher: Datamonitor Healthcare
- Description
- Contents
This Market Spotlight report covers the Pancreatic Cancer market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, upcoming events, probability of success, a 10-year disease incidence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Key Takeaways
- Datamonitor Healthcare estimates that in 2019, there were 462,100 incident cases of pancreatic cancer worldwide, and expects that number to increase to 486,300 incident cases by 2028.
- The approved drugs in the pancreatic cancer space target microtubules (tubulin), DNA, DNA synthesis, topoisomerase I, poly ADP-ribose polymerase (PARP), dihydropyrimidine dehydrogenase, thymidylate synthase, and epidermal growth factor receptor (EGFR). These drugs are commonly administered via the intravenous route, with a few select products being available in oral and intratumoral formulations.
- The majority of industry-sponsored drugs in active clinical development for pancreatic cancer are in Phase II. Therapies in development for pancreatic cancer focus on a wide variety of targets. The majority of pipeline drugs for pancreatic cancer are administered via the oral or intravenous routes.
- High-impact upcoming events for drugs in the pancreatic cancer space comprise topline Phase II trial results for motixafortide; topline Phase III trial results for EndoTAG-1, CPI-613, ERY-ASP, pamrevlumab, and Onivyde; and an expected patent expiration for Abraxane.
- The overall likelihood of approval of a Phase I pancreatic cancer asset is 1.9%, and the average probability a drug advances from Phase III is 13.8%. Drugs, on average, take 10.7 years from Phase I to approval, compared to 9.6 years in the overall oncology space.
- The distribution of clinical trials across Phase I–IV indicates that the vast majority of trials for pancreatic cancer have been in the early and mid-phases of development, with 93% of trials in Phase I–II, and only 7% in Phase III–IV.
- The US has a substantial lead in the number of pancreatic cancer clinical trials globally. The UK leads the major European markets, while Japan has the top spot in Asia.
- Clinical trial activity in the pancreatic cancer space is dominated by completed trials. Roche has the highest number of completed clinical trials for pancreatic cancer, with 106 trials.
- Bristol Myers Squibb leads industry sponsors with the highest overall number of clinical trials for pancreatic cancer, followed by Roche.
CONTENTS
6 OVERVIEW
7 KEY TAKEAWAYS
8 DISEASE BACKGROUND
8 Subtypes
9 TREATMENT
9 Surgery
9 Ablation or embolization
10 Radiation therapy
10 Chemotherapy
10 Targeted therapy
11 Immunotherapy
11 Drugs used specifically for the treatment of PNETs
12 EPIDEMIOLOGY
15 MARKETED DRUGS
18 PIPELINE DRUGS
35 RECENT EVENTS AND ANALYST OPINION
35 Motixafortide for Pancreatic Cancer (December 16, 2020)
36 Masitinib for Pancreatic Cancer (December 4, 2020)
38 Motixafortide for Pancreatic Cancer (January 24, 2020)
39 Lynparza for Pancreatic Cancer (December 17, 2019)
41 KEY UPCOMING EVENTS
42 PROBABILITY OF SUCCESS
43 LICENSING AND ASSET ACQUISITION DEALS
43 Laevoroc Oncology Acquires Worldwide Patents For LR06
43 Lantern Pharma Enters Research And Development Collaboration with Actuate Therapeutics
43 CytoImmune Acquires City Of Hope Cell Therapy IP
43 University of Texas MD Anderson Cancer Center Unveils Collaboration With TriSalus Life Sciences
43 MD Anderson Inks New Cancer Collaboration With Mirati, Orionis
44 Qilu Obtains Greater China Rights To Cend’s Cancer Candidate
44 Agios Sells Cancer Portfolio To Servier To Focus On Genetic Diseases
44 NantKwest/ImmunityBio To Merge In All-Stock Deal
44 Dong-A, Jiangsu Hengrui Ink Next-Generation IO License Deal
45 Cytocom Goes Public Via Merger With Cleveland BioLabs
45 Exact Goes All-In On Multi-Cancer Screening With $2.15Bn For Thrive; $410M For Base Genomics
45 TriSalus Thinks Its Drug/Device Strategy Can Optimize IO Regimens
46 Processa Licenses IP For Next-Generation Irinotecan From Aposense
47 REVENUE OPPORTUNITY
50 CLINICAL TRIAL LANDSCAPE
51 Sponsors by status
52 Sponsors by phase
53 Recent events
55 BIBLIOGRAPHY
56 APPENDIX
LIST OF FIGURES
14 Figure 1: Trends in incident cases of pancreatic cancer, 2019–28
18 Figure 2: Overview of pipeline drugs for pancreatic cancer in the US
18 Figure 3: Pipeline drugs for pancreatic cancer, by company
19 Figure 4: Pipeline drugs for pancreatic cancer, by drug type
19 Figure 5: Pipeline drugs for pancreatic cancer, by classification
36 Figure 6: Motixafortide for Pancreatic Cancer (December 16, 2020): Phase IIa – COMBAT/KEYNOTE-202 (w/Keytruda)
38 Figure 7: Masitinib for Pancreatic Cancer (December 4, 2020): Phase III – AB12005
39 Figure 8: Motixafortide for Pancreatic Cancer (January 24, 2020): Phase Ib/II – w/Atezolizumab
41 Figure 9: Key upcoming events in pancreatic cancer
42 Figure 10: Probability of success in the pancreatic cancer pipeline
50 Figure 11: Clinical trials in pancreatic cancer
50 Figure 12: Top 10 drugs for clinical trials in pancreatic cancer
51 Figure 13: Top 10 companies for clinical trials in pancreatic cancer
51 Figure 14: Trial locations in pancreatic cancer
52 Figure 15: Pancreatic cancer trials status
53 Figure 16: Pancreatic cancer trials sponsors, by phase
LIST OF TABLES
13 Table 1: Incident cases of pancreatic cancer, 2019–28
16 Table 2: Marketed drugs for pancreatic cancer
20 Table 3: Pipeline drugs for pancreatic cancer in the US
35 Table 4: Motixafortide for Pancreatic Cancer (December 16, 2020)
37 Table 5: Masitinib for Pancreatic Cancer (December 4, 2020)
38 Table 6: Motixafortide for Pancreatic Cancer (January 24, 2020)
40 Table 7: Lynparza for Pancreatic Cancer (December 17, 2019)
48 Table 8: Historical global sales, by drug ($m), 2016–20
49 Table 9: Forecasted global sales, by drug ($m), 2021–25
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