Market Spotlight: Thyroid Cancer
Market Spotlight: Thyroid Cancer
This Market Spotlight report covers the Thyroid cancer market, comprising key pipeline and marketed drugs, clinical trials, upcoming and regulatory events, patent information, a 10-year disease incidence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Author: Informa Pharma Intelligence
Publisher: Datamonitor Healthcare
This Market Spotlight report covers the thyroid cancer market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, key upcoming and regulatory events, probability of success, patent information, a 10-year disease incidence and five-year prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
- Datamonitor Healthcare estimates that in 2017, there were 559,800 incident cases of thyroid cancer worldwide, and expects that number to increase to 612,600 incident cases by 2026.
- In the same year, there were an estimated 2.0 million five-year prevalent cases of thyroid cancer worldwide, which is expected to increase to 2.2 million cases by 2026.
- The approved drugs in the thyroid cancer space focus on a wide variety of targets. These drugs are commonly administered via the oral route, with one product being available in an intramuscular formulation.
- The largest proportion of industry-sponsored drugs in active clinical development for thyroid cancer are in Phase II, with only one drug in the NDA/BLA stage.
- Therapies in early-to-mid-stage development for thyroid cancer focus on targets such as RET, carcinoembryonic antigen, immune system, tumor necrosis factor-alpha, and ErbB3/HER3. These therapies are administered via the oral, intravenous, and subcutaneous routes.
- High-impact upcoming events for drugs in the thyroid cancer space comprise topline Phase III trial results for Cometriq, and an estimated PDUFA date as well as a CHMP opinion for selpercatinib.
- The overall likelihood of approval of a Phase I solid tumors asset is 5.7%, and the average probability a drug advances from Phase III is 41.9%. Drugs, on average, take 9.4 years from Phase I to approval, compared to 9.3 years in the overall oncology space.
- There have been 14 licensing and asset acquisition deals involving thyroid cancer drugs during 2015–20. The $1,550m exclusive global collaboration signed in November 2017 between Bayer and Loxo Oncology for the development and commercialization of two novel oncology therapies selectively targeting genetic drivers of cancer was the largest deal.
- The distribution of clinical trials across Phase I–IV indicates that the vast majority of trials for thyroid cancer have been in the early and mid-phases of development, with 91% of trials in Phase I–II, and only 9% in Phase III–IV.
- The US has a substantial lead in the number of thyroid cancer clinical trials globally. France leads the major European markets, while China has the top spot in Asia.
- Clinical trial activity in the thyroid cancer space is dominated by completed trials. Pfizer has the highest number of completed clinical trials for thyroid cancer, with 33 trials.
- Novartis leads industry sponsors with the highest overall number of clinical trials for thyroid cancer, followed by Pfizer.
7 KEY TAKEAWAYS
8 DISEASE BACKGROUND
10 Radioactive iodine (RAI) therapy
10 Thyroid hormone therapy
10 External beam radiation therapy
11 Targeted therapy
16 MARKETED DRUGS
19 PIPELINE DRUGS
23 RECENT EVENTS AND ANALYST OPINION
23 Selpercatinib for Thyroid Cancer (September 29, 2019)
24 Pralsetinib for Thyroid Cancer (June 3, 2019)
25 Pralsetinib for Thyroid Cancer (May 15, 2019)
28 KEY UPCOMING EVENTS
29 KEY REGULATORY EVENTS
29 Keeping Track: Year-End Submissions Rush Brings Seven Novel Agents To US FDA
30 PROBABILITY OF SUCCESS
31 LICENSING AND ASSET ACQUISITION DEALS
32 PARENT PATENTS
33 REVENUE OPPORTUNITY
34 CLINICAL TRIAL LANDSCAPE
35 Sponsors by status
36 Sponsors by phase
37 Lilly’s Loxo Bet Pays Off In Thyroid Cancer, A Second Indication For Selpercatinib
38 Prescription information
LIST OF FIGURES
14 Figure 1: Trends in incident cases of thyroid cancer, 2017–26
19 Figure 2: Overview of pipeline drugs for thyroid cancer in the US
19 Figure 3: Pipeline drugs for thyroid cancer, by company
20 Figure 4: Pipeline drugs for thyroid cancer, by drug type
20 Figure 5: Pipeline drugs for thyroid cancer, by classification
24 Figure 6: Selpercatinib for Thyroid Cancer (September 29, 2019): Phase I/II – LIBRETTO-001
25 Figure 7: Pralsetinib for Thyroid Cancer (June 3, 2019): Phase I/II – ARROW (NSCLC, Thyroid, Solids)
27 Figure 8: Pralsetinib for Thyroid Cancer (May 15, 2019): Phase I/II – ARROW (NSCLC, Thyroid, Solids)
28 Figure 9: Key upcoming events in thyroid cancer
30 Figure 10: Probability of success in the thyroid cancer pipeline
31 Figure 11: Licensing and asset acquisition deals in thyroid cancer, 2015–20
32 Figure 12: Parent patents in thyroid cancer
34 Figure 13: Clinical trials in thyroid cancer
34 Figure 14: Top 10 drugs for clinical trials in thyroid cancer
35 Figure 15: Top 10 companies for clinical trials in thyroid cancer
35 Figure 16: Trial locations in thyroid cancer
36 Figure 17: Thyroid cancer trials status
37 Figure 18: Thyroid cancer sponsors, by phase
LIST OF TABLES
13 Table 1: Incident cases of thyroid cancer, 2017–26
15 Table 2: Five-year prevalent cases of thyroid cancer, 2017–26
17 Table 3: Marketed drugs for thyroid cancer
21 Table 4: Pipeline drugs for thyroid cancer in the US
23 Table 5: Selpercatinib for Thyroid Cancer (September 29, 2019)
24 Table 6: Pralsetinib for Thyroid Cancer (June 3, 2019)
26 Table 7: Pralsetinib for Thyroid Cancer (May 15, 2019)
33 Table 8: Historical global sales, by drug ($m), 2014–18
33 Table 9: Forecasted global sales, by drug ($m), 2020–24
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