Recentin
Publisher: Datamonitor Healthcare
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Drug Overview
Recentin (cediranib; AstraZeneca) is a small molecule inhibitor of all three vascular endothelial growth factor receptor (VEGFR-1, -2, -3) tyrosine kinases. The VEGF family of receptors are critical for angiogenesis and their overexpression in ovarian tumors is a sign of poor prognosis. Inhibiting the VEGF pathway blocks signaling that promotes angiogenesis and thereby inhibits tumor progression.
Analyst Outlook
To date, Recentin (cediranib; AstraZeneca) is the only targeted therapy developed for ovarian cancer to demonstrate that it extends overall survival (OS). This will serve to distinguish it from currently marketed drugs in the recurrent platinum-sensitive setting, which have not shown that they extend OS. If approved, Recentin could greatly increase AstraZeneca’s share of the ovarian cancer market as it targets a larger patient population than AstraZeneca’s other approved drug, Lynparza (olaparib), and it is being evaluated as both an induction and maintenance therapy.
TABLE OF CONTENTS
4 PRODUCT PROFILES
4 Recentin : Ovarian cancer
LIST OF FIGURES
8 Figure 1: Recentin for ovarian cancer – SWOT analysis
9 Figure 2: Datamonitor Healthcare’s drug assessment of Recentin for ovarian cancer
10 Figure 3: Datamonitor Healthcare’s drug assessment of Recentin for ovarian cancer
LIST OF TABLES
4 Table 1: Recentin drug profile
5 Table 2: Recentin Phase III data in ovarian cancer
6 Table 3: Recentin Phase III results in ovarian cancer
7 Table 4: Overview of early phase data for Recentin in ovarian cancer
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