Remicade

TABLE OF CONTENTS

5 OVERVIEW
5 Drug Overview
6 Product Profiles
6 Remicade : Crohn’s disease
23 Remicade : Axial spondyloarthritis (axSpA)
35 Remicade : Rheumatoid arthritis (RA)
47 Remicade : Psoriatic arthritis (PsA)
59 Remicade : Ulcerative colitis
74 Remicade : Psoriasis

LIST OF FIGURES
14 Figure 37: Upadacitinib sales for Crohn’s disease across the US, Japan, and five major EU markets, by country, 2016–25
16 Figure 19: Datamonitor Healthcare’s drug assessment summary of Humira in Crohn’s disease
19 Figure 6: Sales of filgotinib and upadacitinib across the US, Japan, and five major EU markets, by drug, 2016–25
26 Figure 20: Humira sales for Crohn’s disease across the US, Japan, and five major EU markets, by country, 2016–25
27 Figure 2: Datamonitor Healthcare’s drug assessment summary of Alofisel in Crohn’s disease
31 Figure 18: Remicade for Crohn’s disease – SWOT analysis
53 Figure 3: Datamonitor Healthcare’s drug assessment summary of Alofisel in Crohn’s disease
54 Figure 6: Entyvio for Crohn’s disease – SWOT analysis
68 Figure 8: Humira for Crohn’s disease – SWOT analysis
69 Figure 24: Datamonitor Healthcare’s drug assessment summary of Tysabri in Crohn’s disease
80 Figure 11: Remicade for Crohn’s disease – SWOT analysis
81 Figure 33: Filgotinib for Crohn’s disease – SWOT analysis

LIST OF TABLES
7 Table 1: Remicade drug profile
9 Table 2: Remicade pivotal trial data in adult Crohn’s disease
13 Table 3: Remicade pivotal trial data in pediatric Crohn’s disease
20 Table 4: Remicade sales for Crohn’s disease across the US, Japan, and five major EU markets, by country ($m), 2016–25
23 Table 5: Remicade drug profile
26 Table 15: Entyvio sales for Crohn’s disease across the US, Japan, and five major EU markets, by country ($m), 2016–25
32 Table 7: Remicade sales for axial spondyloarthritis across the US, Japan, and five major EU markets, by country ($m), 2016–25
36 Table 8: Remicade drug profile
40 Table 9: Remicade late-phase trial data in rheumatoid arthritis
48 Table 10: Remicade drug profile
50 Table 11: Remicade pivotal trial data in psoriatic arthritis
60 Table 12: Remicade drug profile
62 Table 13: Remicade pivotal trial data in ulcerative colitis
75 Table 14: Remicade drug profile
77 Table 15: Remicade pivotal trial data in psoriasis
78 Table 16: Remicade ongoing late-phase clinical trials in psoriasis
79 Table 25: Etrolizumab drug profile