Table of Contents

Executive Summary………………………………………………………………………………………… ES-1
i. Global market for robotically assisted surgical systems…………………………………………………..ES-1
ii. Methodology ……………………………………………………………………………………………………………ES-4

Exhibit ES-1: Robotically assisted surgical devices market ($m), share by country/region, 2020 ………………………………………………………………………….ES-1
Exhibit ES-2: Robotically assisted surgical devices, global market forecast ($m), by country/region, 2020–25 …………………………………..ES-2

1. Robotically Assisted Surgery ……………………………………………………………………………1-1
1.1 Robotically assisted procedures……………………………………………………………………………….. 1-2
1.2 Clinical applications………………………………………………………………………………………………… 1-3
1.2.1 Brain surgery ……………………………………………………………………………………… 1-3
1.2.2 Cardiothoracic surgery………………………………………………………………………… 1-3
1.2.3 General surgery………………………………………………………………………………….. 1-4
1.2.4 Gynecologic……………………………………………………………………………………….. 1-6
1.2.5 Head and neck……………………………………………………………………………………. 1-6
1.2.6 Orthopedic and spine………………………………………………………………………….. 1-7
1.2.7 Urologic…………………………………………………………………………………………….. 1-7
1.3 Selected FDA adverse-event reports…………………………………………………………………………. 1-7
1.4 Bibliography…………………………………………………………………………………………………………… 1-9

Exhibit 1-1: Advantages and disadvantages of robotically assisted surgery……………………………… 1-1
Exhibit 1-2: Intuitive Surgical’s da Vinci surgical system procedure volumes, by clinical application and geographic area, 2018–20 …………………………………………. 1-3

2. Robotically Assisted Surgical Devices………………………………………………………………..2-1
2.1 Robotic systems by clinical application ……………………………………………………………………… 2-1
2.1.1 Bronchoscopy…………………………………………………………………………………….. 2-7
2.1.2 Cardiovascular……………………………………………………………………………………. 2-8
2.1.3 General surgery………………………………………………………………………………….. 2-9
2.1.4 Gynecology and urology ……………………………………………………………………. 2-10
2.1.5 Hair transplant …………………………………………………………………………………. 2-10
2.1.6 Head and neck………………………………………………………………………………….. 2-10
2.1.7 Neurovascular………………………………………………………………………………….. 2-11
2.1.8 Stereotactic brain procedures ……………………………………………………………. 2-11
2.1.9 Orthopedic ………………………………………………………………………………………. 2-11
2.1.10 Brain and spine ………………………………………………………………………………. 2-14
2.1.11 Organ transplant…………………………………………………………………………….. 2-16
2.1.12 Peripheral vascular………………………………………………………………………….. 2-16
2.1.13 Thoracic…………………………………………………………………………………………. 2-16
2.2 Emerging products………………………………………………………………………………………………… 2-17
2.3 Instruments and holders ……………………………………………………………………………………….. 2-21
2.4 Bibliography…………………………………………………………………………………………………………. 2-25

Exhibit 2-1: Intuitive Surgical’s robotically assisted surgical systems, instruments, and accessories, 2021……………………………………………………………………………. 2-2
Exhibit 2-2: Intuitive Surgical’s da Vinci S surgical system…………………………………………………………. 2-3
Exhibit 2-3: Selected robotically assisted surgery systems, 2021……………………………………………….. 2-4
Exhibit 2-4: Auris Health/Johnson & Johnson’s Monarch platform ……………………………………………. 2-8
Exhibit 2-5: Selected robotically assisted surgery systems for orthopedic applications, 2021 ……………………………………………………………………………………………………………….. 2-12
Exhibit 2-6: Johnson & Johnson’s Velys robotic surgery system ………………………………………………. 2-13
Exhibit 2-7: Selected robotically assisted surgery systems for brain and spine applications, 2021 ……………………………………………………………………………………………………………….. 2-15
Exhibit 2-8: Selected emerging robotically assisted surgery devices, 2021 ……………………………….. 2-18
Exhibit 2-9: Medtronic’s Hugo system………………………………………………………………………………….. 2-19
Exhibit 2-10: Emerging robotic platform for ophthalmology applications, 2021………………………… 2-21
Exhibit 2-11: Selected roboticized instruments/holders, 2021 ………………………………………………… 2-24

3. Market for Robotically Assisted Surgery Systems ……………………………………………….3-1
3.1 Global market forecast ……………………………………………………………………………………… 3-1
3.2 Competitive analysis……………………………………………………………………………………….. 3-12
3.2.1 Selected acquisitions…………………………………………………………………………. 3-23
3.3 Bibliography …………………………………………………………………………………………………… 3-25

Exhibit 3-1: Robotically assisted surgical devices market, share by country/region, 2020…………….. 3-1
Exhibit 3-2: Robotically assisted surgical devices, market forecast ($m), by country/region, 2020–25 ……………………………………………………………………………………………………………. 3-2
Exhibit 3-3: Robotically assisted surgery, market forecast by supplier and region ($m), 2020–25 ……………………………………………………………………………………………………………. 3-3
Exhibit 3-4: Average sales prices of selected robotically assisted surgical devices……………………… 3-10
Exhibit 3-5: Robotically assisted surgical devices market ($m), global share by supplier, 2020 ……………………………………………………………………………………………………………….. 3-13
Exhibit 3-6: Accuray’s CyberKnife estimated revenue, 2020……………………………………………………. 3-14
Exhibit 3-7: Robotically assisted surgery system sales ($m), share by supplier by region, 2020 ……………………………………………………………………………………………………………….. 3-15
Exhibit 3-8: Intuitive Surgical historical revenue ($m), 2018–20………………………………………………. 3-16
Exhibit 3-9: Intuitive Surgical’s installed base and systems shipped, US, 2018–20……………………… 3-17
Exhibit 3-10: Intuitive Surgical’s installed base and systems shipped, Outside US, 2018–20 ……….. 3-18
Exhibit 3-11: Intuitive Surgical global market forecast ($m), 2020–25 ……………………………………… 3-20
Exhibit 3-12: MAKO installed base for total knee arthroplasty, 2018–20 ………………………………….. 3-21

APPENDIX: COMPANY LISTING …………………………………………………………………………………… A-1