Injectable semaglutide (Novo Nordisk) is a once-weekly glucagon-like peptide-1 (GLP-1) agonist currently seeking approval for the treatment of type 2 diabetes. It is a sustained-release formulation GLP-1 agonist and therefore acts on the incretin system. Semaglutide is structurally similar to Victoza (liraglutide; Novo Nordisk), with two modifications: Gly in position eight is replaced by Aib, and the fatty acid side chain has been modified to bind to albumin in circulation to prolong semaglutide’s half-life. This increased half-life allows for once-weekly dosing.
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4 PRODUCT PROFILES
4 semaglutide (Injectable) : Diabetes type 2
LIST OF FIGURES 9 Figure 1: Injectable semaglutide for type 2 diabetes – SWOT analysis
10 Figure 2: Datamonitor Healthcare’s drug assessment summary of injectable semaglutide for type 2 diabetes
11 Figure 3: Datamonitor Healthcare’s drug assessment summary of injectable semaglutide for type 2 diabetes
LIST OF TABLES 6 Table 2: Injectable semaglutide Phase III data in type 2 diabetes
14 Table 2: Injectable semaglutide sales for type 2 diabetes across the US, Japan, and five major EU markets, by country ($m), 2016–25
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