Table of Contents

Executive Summary …………………………………………………………………….. ES-1
i. Heart valve disorders overview ………………………………………………………………………… ES-1
ii. Global market for transcatheter heart valve management products………………………. ES-1
a. Market drivers and limiters………………………………………………………………….. ES-3
b. Device segment insights ……………………………………………………………………… ES-4
c. Technology trends………………………………………………………………………………. ES-4
d. Market leaders ………………………………………………………………………………….. ES-5
e. Competitive strategies………………………………………………………………………… ES-5
f. Emerging competition …………………………………………………………………………. ES-5
iii. Methodology……………………………………………………………………………………………….. ES-6

Exhibit ES-1: Transcatheter heart valve management products, combined market forecast ($m), by product segment, 2020–25 …………………….. ES-2
Exhibit ES-2: Transcatheter heart valve management products, combined market forecast ($m), by country/region, 2020–25 ……………………….. ES-3

1. Valvular Heart Disease Overview………………………………………………….1-1
1.1 Types of heart valve disorders………………………………………………………………………….1-2
1.1.1 Valvular stenosis………………………………………………………………………………1-2
1.1.2 Tricuspid valve/pulmonary valve stenosis …………………………………………….1-3
1.1.3 Valvular regurgitation ……………………………………………………………………….1-3
1.2 Conditions associated with heart valve disorders ………………………………………………..1-7
1.2.1 Congenital defects……………………………………………………………………………1-8
1.2.2 Acquired disorders……………………………………………………………………………1-8
1.2.3 Calcific degeneration ………………………………………………………………………..1-8
1.2.4 Infective endocarditis………………………………………………………………………..1-8
1.2.5 Rheumatic fever……………………………………………………………………………….1-9
1.2.6 Heart failure…………………………………………………………………………………..1-10
1.3 Heart valve disorder diagnosis………………………………………………………………………..1-11
1.4 Heart valve disease treatment options…………………………………………………………….1-11
1.4.1 Pharmaceutical treatments………………………………………………………………1-11
1.4.2 Surgical and other interventional solutions…………………………………………1-12
1.5 Bibliography………………………………………………………………………………………………..1-14

Exhibit 1-1: Progression of valvular heart disease ………………………………………………………………..1-2
Exhibit 1-2: Euro Heart Survey on Valvular Heart Disease patient population, native heart valve disorders, by type……………………………………………………………………….1-6
Exhibit 1-3: Types of valvular heart disease and associated conditions of valve disease ……………..1-7

2. Transcatheter Heart Valve Management Products …………………………..2-1
2.1 Transcatheter aortic valve replacement……………………………………………………………..2-1
2.1.1 Products …………………………………………………………………………………………2-2
2.1.2 Emerging TAVR products……………………………………………………………………2-8
2.2 Transcatheter mitral valve replacement …………………………………………………………..2-10
2.2.1 Products ………………………………………………………………………………………..2-11
2.3 Transcatheter mitral valve repair…………………………………………………………………….2-14
2.3.1 Edge-to-edge repair………………………………………………………………………..2-14
2.3.2 Enhanced coaptation/leaflet spacing …………………………………………………2-15
2.3.3 Coronary sinus annuloplasty …………………………………………………………….2-15
2.3.4 Direct annuloplasty …………………………………………………………………………2-17
2.3.5 Chordal repair………………………………………………………………………………..2-17
2.4 Bibliography………………………………………………………………………………………………..2-21

Exhibit 2-1: Selected transcatheter aortic valve replacement products, 2021 ………………..2-7
Exhibit 2-2: Selected emerging transcatheter aortic valve replacement products, 2021…..2-9
Exhibit 2-3: Comparison of transcatheter aortic and mitral valve replacement…………….2-10
Exhibit 2-4: Selected transcatheter mitral and tricuspid valve replacement products, 2021……………………………………………………………………..2-12
Exhibit 2-5: Selected current and emerging transcatheter mitral valve repair products, 2021 ………………………………………………………………………………2-18

3. Transcatheter Heart Valve Products Market……………………………………3-1
3.1 Global market ……………………………………………………………………………………………….3-1
3.1.1 Market value……………………………………………………………………………………3-2
3.1.2 Technology trends ……………………………………………………………………………3-4
3.1.3 Market drivers and limiters………………………………………………………………..3-6
3.1.4 Transcatheter versus surgical heart valve management options……………….3-7
3.2 Transcatheter aortic valve replacement products market……………………………………..3-8
3.2.1 US ……………………………………………………………………………………………..3-9
3.2.2 5 Euro …………………………………………………………………………………………..3-10
3.2.3 Japan ……………………………………………………………………………………………3-11
3.2.4 Rest of World…………………………………………………………………………………3-11
3.2.5 Competitive analysis……………………………………………………………………….3-12
3.3 Transcatheter mitral valve repair products market…………………………………………….3-18
3.3.1 US ……………………………………………………………………………………………3-19
3.3.2 5 Euro …………………………………………………………………………………………..3-20
3.3.3 Japan ……………………………………………………………………………………………3-20
3.3.4 Rest of World…………………………………………………………………………………3-20
3.3.5 Competitive analysis……………………………………………………………………….3-21
3.4 Bibliography………………………………………………………………………………………………..3-24

Exhibit 3-1: Transcatheter heart valve management products, combined market forecast ($m), by product segment, 2020–25 ……………………….3-3
Exhibit 3-2: Transcatheter heart valve management products, combined market forecast ($m), by country/region, 2020–25 ………………………….3-4
Exhibit 3-3: Comparison of surgical aortic valve replacement and transcatheter aortic valve replacement………………………………………………………..3-8
Exhibit 3-4: Transcatheter aortic valve replacement products, market forecast, by region ($m), 2020–25 …………………………………………………….3-9
Exhibit 3-5: Edwards Lifesciences, revenues by segment, FY2020 ………………………………3-13
Exhibit 3-6: Medtronic, revenues by segment, FY2021 …………………………………………….3-14
Exhibit 3-7: Abbott, revenues by segment, FY2020………………………………………………….3-16
Exhibit 3-8: Boston Scientific, revenues by segment, FY2020…………………………………….3-17
Exhibit 3-9: Trancatheter aortic valve replacment products market, global share by supplier, 2020 …………………………………………………………………..3-18
Exhibit 3-10: Transcatheter mitral valve repair products, market forecast, by region ($m), 2020–25…………………………………………………………………………..3-19
Exhibit 3-11: Transcatheter mitral valve repair products market, global share by supplier, 2020 …………………………………………………………………..3-23

Appendix: Company Listing……………………………………………………………. A-1