CONTENTS

EXECUTIVE SUMMARY…………………………………………………………………………. ES-1
i. Methodology……………………………………………………………………….. ES-5
Exhibit ES-1: Global osteoporosis diagnostic products, combined market forecast, 2015-2020 ……………………………………. ES-2
Exhibit ES-2: Global osteoporosis diagnostic products market, share by product type, 2015 ………………………………………………….. ES-4

1. OVERVIEW OF OSTEOPOROSIS…………………………………………………….. 1-1
1.1 Prevalence and Cost ………………………………………………………………. 1-1
1.2 Fracture Incidence and Economic Costs ……………………………………. 1-3
1.3 Types of Osteoporosis…………………………………………………………….. 1-9
1.4 Risk Factors ………………………………………………………………………….. 1-9
1.5 Treatment ……………………………………………………………………………. 1-15
1.6 Bibliography…………………………………………………………………………. 1-16
Exhibit 1-1: Normal bone and osteoporotic bone …………………………………………. 1-2
Exhibit 1-2: Osteoporosis prevalence across the US, Japan, and 5EU, 2015-30 ………………………………………………………………………………… 1-4
Exhibit 1-3: Osteopenia prevalence across the US, Japan, and 5EU, 2015-30 ………………………………………………………………………………… 1-5
Exhibit 1-4: Osteoporosis-caused fracture incidence in the EU, by site …………… 1-6
Exhibit 1-5: US hospitalizations for fragility fractures in women, by site …………… 1-8
Exhibit 1-6: Types of osteoporosis …………………………………………………………… 1-10
Exhibit 1-7: Leading risk factors for osteoporosis ……………………………………….. 1-11
Exhibit 1-8: Population growth of 65+ years age group, 2000-50, selected countries…………………………………………………………………. 1-12

2. BONE DENSITOMETRY PRODUCTS MARKET …………………………………. 2-1
2.1 Bone Densitometry Overview …………………………………………………… 2-1
2.1.1 Dual-energy X-ray absorptiometry………………………………. 2-3
2.1.2 Single-energy X-ray absorptiometry ……………………………. 2-5
2.1.3 Radiographic absorptiometry……………………………………… 2-5
2.1.4 Quantitative computed tomography…………………………….. 2-5
2.1.5 Quantitative ultrasound …………………………………………….. 2-6
2.1.6 Software-based densitometry systems………………………… 2-6
2.1.7 Hospital-based densitometry systems…………………………. 2-9
2.1.8 Office-based densitometry systems ……………………………. 2-9
2.2 Bone Densitometry Products……………………………………………………. 2-9
2.2.1 BeamMed……………………………………………………………….. 2-9
2.2.2 CompuMed……………………………………………………………. 2-10
2.2.3 Furuno Electric Company………………………………………… 2-11
2.2.4 GE Healthcare/General Electric Company …………………. 2-11
2.2.5 Hologic …………………………………………………………………. 2-11
2.2.6 Swissray……………………………………………………………….. 2-12
2.2.7 Emerging………………………………………………………………. 2-12
2.3 Market Analysis ……………………………………………………………………. 2-21
2.3.1 Market forecast: US………………………………………………… 2-23
2.3.1.1 Insurance reimbursement………………………….. 2-24
2.3.2 Market forecast: EU………………………………………………… 2-26
2.3.2.1 DXA utilization…………………………………………. 2-28
2.3.2.2 Insurance reimbursement………………………….. 2-28
2.3.3 Market forecast: Japan……………………………………………. 2-29
2.3.4 Market forecast: rest of the world ……………………………… 2-29
2.3.5 Competitive analysis: global…………………………………….. 2-31
2.3.5.1 Competitive analysis: US ………………………….. 2-32
2.3.5.2 Competitive analysis: EU ………………………….. 2-32
2.3.5.3 Competitive analysis: rest of the world ………… 2-36
2.3.6 Detailed analysis, by competitor……………………………….. 2-36
2.3.6.1 GE Healthcare/General Electric Company …… 2-36
2.3.6.2 Hologic …………………………………………………… 2-38
2.4 Bibliography…………………………………………………………………………. 2-38

Exhibit 2-1: Comparison of biochemical markers and bone densitometr as tools for diagnosing and monitoring osteoporosis……………………. 2-2
Exhibit 2-2: Imaging modalities used to diagnose osteoporosis ……………………… 2-7
Exhibit 2-3: Selected bone densitometry systems ………………………………………. 2-13
Exhibit 2-4: BeamMed’s Sunlight Omnisense 9000 bone sonometer…………….. 2-15
Exhibit 2-5: The Norland family of dual-energy X-ray absorptiometry systems ………………………………………………… 2-16
Exhibit 2-6: GE’s Lunar iDXA dual-energy X-ray absorptiometry system ……….. 2-17
Exhibit 2-7: The Discovery and Horizon dual-energy X-ray absorptiometry systems ………………………………………………… 2-18
Exhibit 2-8: The OsteoGram radiographic absorptiometry system ………………… 2-19
Exhibit 2-9: The CM-200 quantitative ultrasound bone densitometry system….. 2-20
Exhibit 2-10: Bone densitometry systems market forecast, by region, 2015-20………………………………………………………………… 2-22
Exhibit 2-11: Spending on healthcare in the US and selected European countries ……………………………………………. 2-27
Exhibit 2-12: Bone densitometry systems global market, share by supplier, 2015 …………………………………………………………. 2-33
Exhibit 2-13: Bone densitometry systems US market, share by supplier, 2015 …………………………………………………………. 2-34
Exhibit 2-14: Bone densitometry systems EU market, share by supplier, 2015 …………………………………………………………. 2-35
Exhibit 2-15: Bone densitometry systems RoW market, share by supplier, 2015 …………………………………………………………. 2-37

3. GLOBAL MARKET FOR BONE REMODELING BIOCHEMICAL
MARKER TESTS…………………………………………………………………………….. 3-1
3.1 Biochemical Markers Overview ………………………………………………… 3-1
3.1.1 Types of bone turnover markers…………………………………. 3-2
3.1.2 Applications …………………………………………………………….. 3-2
3.1.3 Limitations ………………………………………………………………. 3-6
3.2 Biochemical Marker Testing Products ……………………………………….. 3-7
3.2.1 Alere………………………………………………………………………. 3-7
3.2.2 Beckman Coulter/Danaher ………………………………………… 3-7
3.2.3 Immunodiagnostic Systems……………………………………….. 3-7
3.2.4 Orion Diagnostica/Orion Group ………………………………….. 3-8
3.2.5 Quest Diagnostics ……………………………………………………. 3-8
3.2.6 Quidel…………………………………………………………………….. 3-8
3.2.7 Roche Diagnostics/F Hoffmann-La Roche …………………… 3-8
3.3 Reimbursement ……………………………………………………………………… 3-9
3.4 Market Analysis ……………………………………………………………………. 3-13
3.5 Competitive Analysis …………………………………………………………….. 3-14
3.5.1 Detailed analysis, by competitor……………………………….. 3-14
3.5.1.1 Alere………………………………………………………. 3-17
3.5.1.2 Quidel…………………………………………………….. 3-18
3.5.1.3 Roche Diagnostics/F Hoffmann-La Roche …… 3-18
3.6 Bibliography…………………………………………………………………………. 3-19

Exhibit 3-1: The bone remodeling cycle ……………………………………………………… 3-3
Exhibit 3-2: Comparison of selected bone remodeling biochemical marker tests…………………………………………………………. 3-4
Exhibit 3-3: Selected bone remodeling biochemical marker tests …………………. 3-10
Exhibit 3-4: Bone remodeling biochemical marker tests market forecast, by region, 2015-20………………………………………………………………… 3-15
Exhibit 3-5: Bone remodeling biochemical marker tests global market, share by supplier, 2015 …………………………………………………………. 3-16
APPENDIX: COMPANY LISTING……………………………………………………………… A-1