Zafatek
Author: Kevin Shannon
Publisher: Datamonitor Healthcare
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Drug Overview
Zafatek (trelagliptin; Takeda) is a member of the dipeptidyl peptidase-IV (DPP-IV) inhibitor class. DPP-IV is an enzyme responsible for the rapid degradation of the incretin hormone glucagon-like peptide-1 (GLP-1), which is released postprandially from the gut. Inhibition of DPP-IV augments the amount of active GLP-1, which in turn triggers increased insulin secretion from the pancreas in a glucose-dependent manner and suppresses the release of glucagon, resulting in lowered blood glucose levels.
TABLE OF CONTENTS
4 PRODUCT PROFILES
4 Zafatek : Diabetes type 2
LIST OF TABLES
6 Table 1: Zafatek sales for type 2 diabetes across the US, Japan, and five major EU markets, by country ($m), 2016–25
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